OzENTER-TBI

Australia-Europe NeuroTrauma Effectiveness Research in Traumatic Brain Injury OzENTER-TBI image

The International Initiative for Traumatic Brain Injury Research (InTBIR) is a collaborative effort of the European Commission, the National Institutes of Health, and the Canadian Institutes of Health Research, which aims to coordinate and harmonise clinical research activities across the full spectrum of traumatic brain injuries (TBI) with the long-term goal of improving outcomes and lessening the global burden of TBI. The first component - the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) project, was prioritised for 30 million Euros over six years by the European Commission under the EU Seventh Framework Programme. This Australia-Europe NeuroTrauma Effectiveness Research in Traumatic Brain Injury grant (OzENTER-TBI) supported Australian participation in this unique international collaborative research program.

The collaboration between OzENTER-TBI and CENTER-TBI was formalised in a Consortium Agreement as Monash University, a listed participant in the CENTER-TBI grant proposal (participant 34).

Enabling Australian participation in the new global TBI research effort provided Australian researchers with access to global expertise and to open access databases. Australian researchers were able to access the processes, protocols, and research platforms that CENTER-TBI developed, as well as all other data.

Contact: For further information about this study, please contact the ANZIC-RC Research Manager, Tony Trapani, by email.

Protocol:

OzENTER-TBI Protocol (1.04MB)

Publications include:

Maas AI, Menon DK, Steyerberg EW, et al. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery 2015;76:67-80. PMID: 25525693.

Cnossen MC, Polinder S, Lingsma HF, et al, CENTER-TBI Investigators and Participants. Variation in Structure and Process of Care in Traumatic Brain Injury: Provider Profiles of European Neurotrauma Centers Participating in the CENTER-TBI Study. PLoS One 2016;11:e0161367. PMID: 27571205.

Cnossen MC, Huijben JA, van der Jagt M, et al. Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study. Crit Care 2017;21:233. PMID: 28874206.

Huijben JA, van der Jagt M, Cnossen MC, et al. Variation in Blood Transfusion and Coagulation Management in Traumatic Brain Injury at the Intensive Care Unit: A Survey in 66 Neurotrauma Centers Participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study. J Neurotrauma 2018;35:323-32. PMID: 28825511.

Huijben JA, Volovici V, Cnossen MC, et al. Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. Crit Care 2018;22:90. PMID: 29650049.

van Veen E, van der Jagt M, Cnossen MC, et al, CENTER-TBI Investigators. Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study. Crit Care 2018;22(1):306. PMID: 30446017.

Steyerberg EW, Wiegers E, Sewalt C, et al, CENTER-TBI Participants Investigators. Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurol 2019;18:923-34. PMID: 31526754

Vande Vyvere T, Wilms G, Claes L, et al; Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants. Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research. J Neurotrauma 2019;36:1080-92. PMID: 30259789

van Essen TA, den Boogert HF, Cnossen MC, et al, CENTER-TBI Investigators and Participants. Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study. Acta Neurochir (Wien) 2019;161:435-49. PMID: 30569224.

Andelic N, Ree C, Brunborg C, et al, CENTER-TBI participants investigators. Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study. J Neurology 2020;epub. PMID: 32676767.

Feng J, van Veen E, Yang C, et al, Collaborative European Neuro Trauma Effectiveness Research in Traumatic Brain Injury Investigators and Participants. Comparison of Care System and Treatment Approaches for Patients with Traumatic Brain Injury in China versus Europe: A CENTER-TBI Survey Study. J Neurotrauma 2020;epub. PMID: 32174214.

Gravesteijn B, Nieboer d, Ercole A, et al, and the CENTER-TBI collaborators. Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. J Clin Epidemiol 2020;20:95-107. PMID: 32201256.

Gravesteijn BY, Sewalt CA, Ercole A, et al, CENTER-TBI Collaborators. Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study. J Neurotrauma 2020;37:1002-10. PMID: 31672086.

Gravesteijn BY, Sewalt CA, Ercole A, et al, CENTER-TBI Collaborators. Variation in the practice of tracheal intubation in Europe after traumatic brain injury: a prospective cohort study. Anaesthesia 2020;75:45-53. PMID: 31520421.

Gravesteijn BY, Sewalt CA, Nieboer D, et al, CENTER-TBI Collaborators. Tracheal intubation in traumatic brain injury: a multicentre prospective observational study. Br J Anaesth 2020;epub. PMID: 32747075.

Huie JR, Mondello S, Lindsell CJ, et al; TRACK-TBI Investigators, CENTER-TBI Investigators. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. J Neurotrauma 2020:epub. PMID: 32046588.

Huijben JA, Wiegers EJA, Ercole A, et al, CENTER-TBI Investigators and Participants for the ICU stratum. Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study. Crit Care 2020;24:78. PMID: 32131882.

Huijben JA, Wiegers EJA, Lingsma HF, et al, CENTER-TBI Investigators. Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe: a CENTER-TBI analysis. Intensive Care Med 2020:46:995-1004. PMID: 32100061.

Jacob L, Cogne M, Tenovuo O, Roe C, et al, CENTER-TBI Participants and Investigators. Predictors of Access to Rehabilitation in the Year Following Traumatic Brain Injury: A European Prospective and Multicenter Study. Neurorehabil Neural Repair 2020;34:814-30. PMID: 32762407.

Mathieu F, Guting H, Gravesteijn B, et al, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Investigators and Participants. Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis. J Neurotrauma 2020:epub. PMID: 32312149.

Robba C, Galimberti S, Graziano F, et al, CENTER-TBI ICU Participants and Investigators. Tracheostomy Practice and Timing in Traumatic Brain-Injured Patients: A CENTER-TBI Study. Intensive Care Med 2020:epub. PMID: 32025780.

Robba C, Rebora P, Banzato E, et al, CENTER-TBI Participants and Investigators. Incidence, Risk Factors, and Effects on Outcome of Ventilator-Associated Pneumonia in Patients With Traumatic Brain Injury: Analysis of a Large, Multicenter, Prospective, Observational Longitudinal Study. Chest 2020 Jul 4;S0012-3692(20)31866-3. PMID: 32634435.

Timmers M, van Dijck J, van Wijk RPJ, et al, CENTER-TBI investigators and participants. How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study. BMC Med Ethics 2020;21:36. PMID: 32398066.

Vande Vyvere T, De La Rosa E, Wilms G, et al, CENTER-TBI Investigators. Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study. J Neurotrauma 2020:epub. PMID: 31813313.

van Wijk RPJ, van Dijck J, Timmers M, et al, CENTER-TBI investigators and participants. Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study. J Crit Care 2020;59:6-15. PMID: 32485440.

Voormolen DC, Polinder S, von Steinbuechel N, et al, the CENTER-TBI participants and investigators. Health‑related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI‑OS for Italy, The Netherlands and The United Kingdom. Qual Life Res 2020;epub. PMID: 32671617.

For further information please refer to these websites:

https://researchdata.ands.org.au/ozenter-tbiaustralia-europe-tbi-collaboration/455584

http://www.iscrr.com.au/living-with-brain-or-spinal-cord-injury/consequences-of-spinal-and-brain-injury/oz-enter

https://www.center-tbi.eu/

https://intbir.nih.gov/