Our research

We hold expertise in large-scale clinical trials, observational studies, feasibility projects, health economics investigations and qualitative research projects. Our networks give us access to biostatisticians and research methodology experts that ensure our trials are robust, effective and efficient.

Protocols and Statistical Analysis Plans

Research programs

Intensive care is the last line of defence when health goes seriously wrong; the most vulnerable patients are found in Intensive Care Units (ICUs), where they receive around the clock care from multi-disciplinary medical and healthcare teams who are specially trained for this purpose.
CRE-ICU works to improve patient outcomes and reduce overall costs, through a suite of research projects that will identify and streamline best care practices. Particular emphasis is placed on invasive life support treatments, such as ECMO.
Led by: Professor Carol Hodgson
Go to CRE-ICU
The Acute Brain Injury Program aims to:
- Foster a coordinated and inter-disciplinary approach to caring for brain injured critically ill patients in Australia and New Zealand
- Enhance knowledge, education, and training in neurocritical care practice in Australia and New Zealand
- Promote a collaborative research agenda aimed at improving long-term outcomes for brain injured patients
Led by: Professor Andrew Udy
Go to ANZIC-RC Acute Brain Injury Program
The Extracorporeal Membrane Oxygenation (ECMO) Program aims to:
- Create a partnership with ECMO centres in Australia and New Zealand to identify gaps in evidence-based care
- Enhance knowledge, education, and training in the provision of ECMO in Australia and New Zealand
- Promote a collaborative research agenda aimed at improving long-term outcomes for critically ill patients who receive ECMO
Led by: Professor Carol Hodgson and Associate Professor Aidan Burrell
Go to ANZIC-RC Binational ECMO Program
The Health Economics Program aims to:
- Promote the inclusion of economic analyses in intensive care clinical trials
- Develop standard methodology for economic evaluation alongside intensive care trial
- Develop methods to efficiently collect resource use data in trial cohorts (including data linkage for post-hospital healthcare resource use and the addition of resource use data points into existing intensive care (and other) databases)
- Develop standardised costings for use in intensive care economic evaluations
- Provide opportunities for mentoring and for health economics training relevant to critical care
Led by: Dr Lisa Higgins
Go to ANZIC-RC Health Economics Program
The Mechanical Ventilation Program aims to:
- Conduct high quality, meaningful research that addresses the needs of consumers and generates new knowledge to impact global mechanical ventilation practice for critically ill patients
- Improve capacity and skill in mechanical ventilation research across Australia and New Zealand
- Support and mentor academic clinician researchers of all disciplines with an interest in mechanical ventilation
Led by: Dr Ary Serpa Neto
Go to ANZIC-RC Mechanical Ventilation Program
The Nutrition Program aims to:
- Conduct high quality, meaningful research that addresses the needs of consumers and generates new knowledge to impact global nutrition care for critically ill patients
- Improve capacity and skill in critical care nutrition research across Australia and New Zealand
- Support and mentor academic clinician researchers of all disciplines with an interest in critical care nutrition
Led by: Associate Professor Emma Ridley
Go to ANZIC-RC Nutrition Program
The Recovery Program aims to:
- Foster a coordinated and interprofessional approach to measuring and treating the long-term sequelae of critical illness
- Develop best-practice methodology for the measurement of patient-reported outcomes alongside clinical trials
- Measure outcomes that are important to patients, consumers, clinicians and healthcare providers to inform long-term recovery after critical illness
- Develop and test novel interventions to improve long-term recovery after critical illness
Led by: Professor Carol Hodgson
Go to ANZIC-RC Recovery Program
The National Critical Care Sepsis Program aims to:
- Establish a learning health care system to improve the outcome for patients diagnosed with sepsis
- Build capacity and infrastructure aimed at improving the experiences and outcomes of patients diagnosed with sepsis who are admitted to an intensive care unit
- Co-design future sepsis projects and build an Australian Critical Care Sepsis Research Roadmap
- Develop IT infrastructure to allow sustainable data integration
- Translate and develop benchmarking, evidence summaries and, potentially, clinical guidelines
Led by: Professor Andrew Udy
Go to the ANZIC-RC National Critical Care Sepsis Program
Renal and metabolic management plays a critical role in the care of critically ill patients. However, these interventions can also lead to complications such as acute kidney injury, metabolic acidosis and metabolic derangements. Therefore, there is an urgent need to advance renal and metabolic strategies to optimize patient outcomes, minimize complications, and improve the quality of care.
Led by: Dr Ary Serpa Neto
Go to ANZIC-RC Renal and Metabolic Program
This program focuses on Medical Emergency Team (METs) and In-hospital cardiac arrests (IHCAs) in Australia.
Over the next 5 years, the aims of the program are to:
1. Establish a national registry for MET calls and IHCAs
2. Evaluate the interaction between frailty and treatment limitations in MET calls
3. Assess the frequency, treatment and outcomes for sepsis during MET calls
By assessing the contemporaneous evidence around the causes and
contributing factors to MET calls and IHCAs the aim is to identify strategies to
reduce their occurrence and improve their outcomes once they have occurred.
Led by: Prof Daryl Jones
Go to ANZIC-RC MET Call and In-Hospital Cardiac Arrest Program

Active research studies

Completed research studies

Read about our completed research studies here.

Our research

Protocols and Statistical Analysis Plans

Research programs

CRE TO TRANSFORM OUTCOMES OF CRITICALLY ILL PATIENTS IN ICU

ACUTE BRAIN INJURY PROGRAM

BINATIONAL ECMO PROGRAM

HEALTH ECONOMICS PROGRAM

MECHANICAL VENTILATION PROGRAM

NUTRITION PROGRAM

RECOVERY PROGRAM

NATIONAL CRITICAL CARE SEPSIS PROGRAM

RENAL AND METABOLIC PROGRAM

MET CALLS AND IN-HOSPITAL CARDIAC ARREST PROGRAM

Active research studies

ARISE-FLUIDS

BONANZA

BONE-ZONE

CLIP-II

DRIVE

ECMO-PROMPT

ECMO-RECOVERY

ECMO-Rehab

EPO-TRAUMA

EXCEL

FEISTY II

GuARDS

IMPROVE-65

INTENT

LOGICAL

NUTRIENT 2

PANTHER

PRECISE

PRECISION-TBI

RECOMMEND Platform Trial

REDEEM

REMAP-CAP

SODa-BIC

SPRINT-SARI

Completed research studies