ANZIC-RC Mechanical Ventilation Program

The Australian and New Zealand Intensive Care Research Centre Mechanical Ventilation Program is led by Associate Professor Ary Serpa Neto. The aims of the Mechanical Ventilation Program are to:

  • Conduct high quality, meaningful research that addresses the needs of consumers and generates new knowledge to impact global mechanical ventilation practice for critically ill patients
  • Improve capacity and skill in mechanical ventilation research across Australia and New Zealand
  • Support and mentor academic clinician researchers of all disciplines with an interest in mechanical ventilation

The Mechanical Ventilation Research Team includes:

Current Mechanical Ventilation Projects include:

Completed Projects

Published studies:

  1. Development of a New Longitudinal Ordinal Outcome for Clinical Trials in Extracorporeal Membrane Oxygenation Patients. Serpa Neto A, Higgins L, Lorenzi E, et al. Am J Respir Crit Care Med 2025;211(7):1220-1228.
  2. Alternative approaches to analyzing ventilator-free days, mortality and duration of ventilation in critical care research. Serpa Neto A, Bailey M, Shehabi Y, Hodgson CL, Bellomo R. Crit Care Sci 2024;36:e20240246en
  3. Pressure support ventilation in intensive care patients receiving prolonged invasive ventilation. Al-Bassam W, Parikh T, Neto AS, Idrees Y, Kubicki MA, Hodgson CL, Subramaniam A, Reddy MP, Gullapalli N, Michel C, Matthewman MC, Naughton J, Pereira J, Shehabi Y, Bellomo R. Crit Care Resusc. 2023 Oct 18;23(4):394-402.
  4. P0.1 During Pressure Support Ventilation. Chow JWY, Al-Bassam W, Yanase F, O'Brien Z, Bassam A, Hadzakis S, Chaba A, Maeda A, Bellomo R, Serpa Neto A; Pressure Support Ventilation Study Group Investigators. Am J Respir Crit Care Med. 2023;[in press].
  5. Magnitude and time to peak oxygenation effect of prone positioning in ventilated adults with COVID-19 related acute hypoxemic respiratory failure. Rollinson TC, McDonald LA, Rose J, Eastwood G, Costa-Pinto R, Modra L, Maeda A, Bacolas Z, Anstey J, Bates S, Bradley S, Dumbrell J, French C, Ghosh A, Haines K, Haydon T, Hodgson C, Holmes J, Leggett N, McGain F, Moore C, Nelson K, Presneill J, Rotherham H, Said S, Young M, Zhao P, Udy A, Chaba A, Bellomo R, Neto AS. Acta Anaesthesiol Scand. 2023;[in press].
  6. Neuromuscular blockade and oxygenation changes during prone positioning in COVID-19. Rollinson TC, McDonald LA, Rose J, Eastwood G, Costa-Pinto R, Modra L, Maeda A, Bacolas Z, Anstey J, Bates S, Bradley S, Dumbrell J, French C, Ghosh A, Haines K, Haydon T, Hodgson CL, Holmes J, Leggett N, McGain F, Moore C, Nelson K, Presneill J, Rotherham H, Said S, Young M, Zhao P, Udy A, Neto AS, Chaba A, Bellomo R. J Crit Care. 2024 Feb;79:154469.
  7. Low tidal volume ventilation for patients undergoing laparoscopic surgery: a secondary analysis of a randomised clinical trial. Karalapillai D, Weinberg L, Neto AS, Peyton PJ, Ellard L, Hu R, Pearce B, Tan CO, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Wilson A, Liskaser G, Balasubramaniam A, Eastwood G, Bellomo R, Jones DA. BMC Anesthesiol. 2023 Mar 7;23(1):71.
  8. Intraoperative low tidal volume ventilation and the risk of ICD-10 coded delirium and the use for antipsychotic medications. Karalapillai D, Weinberg L, Neto AS, Peyton PJ, Ellard L, Hu R, Pearce B, Tan C, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Appu S, Wilson A, Eastwood G, Bellomo R, Jones DA. BMC Anesthesiol. 2022 May 16;22(1):149.
  9. Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial. Karalapillai D, Weinberg L, Peyton P, Ellard L, Hu R, Pearce B, Tan CO, Story D, O'Donnell M, Hamilton P, Oughton C, Galtieri J, Wilson A, Serpa Neto A, Eastwood G, Bellomo R, Jones DA. JAMA. 2020 Sep 1;324(9):848-858.
  10. Bihari S, Bersten A, Paul E, McGuinness S, Dixon D, Sinha P, Calfee CS, Nichol A, Hodgson C, PHARLAP Study Investigators. Acute respiratory distress syndrome phenotypes with distinct clinical outcomes in PHARLAP trial cohort. Crit Care Resusc 2021;23:163-70.
  11. Hodgson CL, Cooper DJ, Arabi Y, King V, Bersten A, Bihari S, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Paul E, Tuxen D, Vallance S, Young M, Nichol A. Maximal Recruitment Open Lung Ventilation in Acute Respiratory Distress Syndrome (PHARLAP). A Phase II, Multicenter Randomized Controlled Clinical Trial. Am J Respir Crit Care Med 2019;200:1363-72.
  12. Hodgson C, Cooper DJ, Arabi Y, Bennett V, Bersten A, Brickell K, Davies A, Fahey C, Fraser J, McGuinness S, Murray L, Parke R, Tuxen D, Vallance S, Young M, Nichol AD, PHARLAP Study Investigators, the Australian and New Zealand Intensive Care Society Clinical Trials Group. Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure (PHARLAP): a protocol for a phase 2 trial in patients with acute respiratory distress syndrome. Crit Care Resusc 2018;20:139-49.