PHARLAP Pilot Study (Permissive Hypercapnia, Alveolar Recruitment and Limited Airway Pressure)
The PHARLAP pilot trial was a phase II prospective randomized control pilot study with stratification comparing a standard form of ventilation with a ventilatory strategy involving daily recruitment manoeuvres in patients with acute respiratory distress syndrome. The study was conducted at one site, The Alfred Hospital. The outcome measures included clinical intensive care outcome measures as well as biochemical markers of acute inflammation. This study was funded by The Alfred Hospital, Australian and New Zealand College of Anaesthetists (ANZCA) and the Intensive Care Foundation.
In 2011, the PHARLAP protocol was submitted to the NHMRC for consideration to fund a larger phase II trial (n=340) across Australia and New Zealand to compare standard protective lung ventilation with PHARLAP ventilation. The outcome measures will include ventilator free days, ICU and hospital length of stay, survival, quality of life and cost effectiveness.