RELEVENT – Rate of Lower Limb Deep Venous Thrombosis in patients with Traumatic Brain Injury

A pilot observational study

This study looked objectively at the rate of lower limb Deep Venous Thrombosis (DVT) in patients admitted to intensive care with a traumatic brain injury by means of compression ultrasonography. Rates of DVT in this patient population were unknown and thought to be higher than the general ICU population because of the relative contraindication of pharmacological DVT prophylaxis. In addition each patient's blood was analysed by means of a thromboelastogram to quantify the degree of hyper or hypo coaguability. The results of this study will potentially form the basis of practice change in relation to routine inferior vena cava filter placement in this patient cohort and help in the design of a future clinical trial comparing different clot prevention strategies. In addition the results will form part of the preliminary work of a future randomised controlled double blind placebo trial in traumatic brain injury.

The publications relating to this study include:

Praeger AJ, Westbrook AJ, Nichol AD, Wijemunige R, Davies AR, Lyon SM, Wills JL, Bailey M, Rosenfeld JV, Cooper DJ. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study. Crit Care Resusc. 2012 Mar;14(1):10-3.