SAFE-TBI and SAFE-TBI II

The results of the SAFE-TBI Study found that in critically ill patients with traumatic brain injury, albumin resuscitation resulted in higher mortality than saline resuscitation. The aim of the SAFE-TBI ll Study was to determine the mechanisms which caused albumin to be associated with an increased mortality, in particular to determine whether increased brain pressures associated with albumin resuscitation lead to use of therapies with toxic side effects which increased mortality. The study design involved a retrospective chart review of the SAFE TBI cohort of patients. All clinical data relating to intracranial pressure (ICP) and the drugs and interventions used for ICP control, in the SAFE-TBI patients would be recorded.

The study received funding from the Victorian Neurotrauma Initiative.

Collaborators: ANZICS CTG owned study; The George Institute for International Health; NTRI; ANZIC-RC