ECMO-Nutrition

Nutrition Practices Across Hospitalisation in Adult Patients requiring Extracorporeal Membrane Oxygenation in Australia - A National, Registry Linked, Prospective Cohort Study

ECMO-Nutrition is a multi-centre registry linked observational study of nutrition in adult patients receiving ECMO within Australia. This study will describe current nutrition delivery practices and provision across acute hospitalisation and explore the relationship between nutrition provision with in-hospital and long term clinical and functional outcomes in adult patients receiving ECMO.

Primary Aim: To describe current nutrition delivery practices and provision in adult patients who receive ECMO in Australia across hospitalisation.

 

Objectives:

Primary objective:

  1. To quantify energy provision across hospitalisation in patients who receive ECMO in Australia

Secondary objectives:

  1. To quantify protein provision across hospitalisation and energy and protein provision during ICU admission.
  2. To identify aspects of clinical care that impact nutrition delivery across hospitalisation
  3. To describe current nutrition delivery practices across hospitalisation including levels of dietetic service provision
  4. To explore the relationship between nutrition provision across hospitalisation with long-term outcomes
  5. To compare changes in nutrition provision during ICU admission in patients who have received ECMO in Australia over the last decade (2012-2022) using a previous dataset

Rationale: Nutrition therapy is an accepted standard of care in patients who receive ECMO, yet evidence remains sparse resulting in significant variations in practice internationally. Completion of this study will address key knowledge-practice gaps by collecting data on nutrition provision and practice across hospitalisation (including novel data on the period following ICU discharge) in patients who receive ECMO in Australia. Additionally, linkage with the Australian and New Zealand extracorporeal membrane oxygenation registry (EXCEL) provides a unique opportunity to explore the association between nutrition provision across hospitalisation with clinical and long-term functional outcomes. The findings from this study will inform nutrition practice changes and guide future research priorities in adult patients receiving ECMO.

Collaboration: Nine ECMO centres across Australia participated in ECMO-Nutrition.

Study progress: Recruitment to ECMO-Nutrition was completed on 9 July 2023. A total of 150 patients were recruited across nine sites within Australia. Analysis has been completed, with the manuscript in progress

Registration: ACTRN12623000304639

Funding: This study is partially funded by the AuSPEN Novice Investigator Grant, with additional funding provided the Chief Investigator’s NHMRC Emerging Leadership Level 1 Fellowship.

Study Contact: