MEASURE
Measured energy expenditure in critically ill adult patients: a retrospective analysis of 10 years of indirect calorimetry data in an Australian Intensive Care Unit
MEASURE was a single-centre retrospective observational study at The Alfred Intensive Care Unit (ICU) in Melbourne. The study included approximately 600 critically ill mechanically ventilated adult patients who had energy requirements measured with indirect calorimetry between January 2010 to July 2019. This was a collaborative research project between the ANZIC-RC and Alfred Health. |  |
Aim:
The primary aim was to describe measured energy expenditure in adult mechanically ventilated critically ill patients.
Rationale:
Indirect calorimetry, a device that measures oxygen consumption and carbon dioxide production, is the recommended method of measuring and guiding energy provision in key international critical illness nutrition guidelines. However, indirect calorimetry is not widely available in Australia and there is minimal data describing measured energy expenditure during ICU admission in a modern setting.
This study provided the largest dataset of measured energy expenditure from Australia in critical illness and will inform future work related to the use of indirect calorimetry in the ICU.
Study Progress:
The study has been completed and is now published - please see the details below.
Registration:
Australian New Zealand Clinical Trials Registry, Trial ID ACTRN12621000007831. Registered 8 January 2021.
Funding:
MEASURE was partly funded by an Advancing Women’s Research Success Grant from the Faculty of Medicine, Nursing and Health Science at Monash University. The remaining work was supported in-kind by the Nutrition Program at the ANZIC-RC.
Publication:
Tatucu-Babet OA, King SJ, Zhang AY, Lambell KJ, Tierney AC, Nyulasi IB, McGloughlin S, Pilcher D, Bailey M, Paul E, Udy A, Ridley EJ. Measured energy expenditure according to the phases of critical illness: A descriptive cohort study. JPEN J Parenter Enteral Nutr. 2025 Apr;49(3):314-323. doi:10.1002/jpen.2721. Epub 2024 Dec 30.