Longitudinal study of diet, lifestyle and biomarker predictors of pouchitis

Subject of area: Inflammatory bowel disease

Title of study: Longitudinal study of diet, lifestyle and biomarker predictors of pouchitis

Brief outline of the study:

Medically non-responsive ulcerative colitis or familial adenomatous polyposis is treated by removing the large intestine and creating a reservoir or 'pouch,' where the end of the small intestine is sewn to the anus. This improves quality of life, however, complications arise such as 'pouchitis,' an inflammatory condition resulting in increased bowel motion and bloody stools. There is little research exploring environmental factors that might determine who and why someone gets pouchitis and another person doesn't.

What is the purpose of this research?

This study aims to follow patients with pouches over 18 months to explore how their pouch functions, dietary factors, stress and biological markers such as the gut microbiome and how this influences the development or worsening of pouchitis. There are no required study visits, all data will be collected electronically and biological samples will be collected at home and returned via post.

Who is eligible to participate?
- Living with an ileoanal pouch
- 18-75 years old
- Living in Australia
- Eligible for Medicare
- Speak and read English

- Internet access

Contact:
Dakota Rhys-Jones
03 9903 0367
Approved by Alfred Health ethics