Our publications
2024 Most Impactful Papers
Zoungas S, Zhou Z, Owen AJ, Curtis AJ, Espinoza SE, Ernst ME, Woods RL, Orchard SG, McNeil JJ, Murray AM, Nelson MR, Reid CM, Ryan J, Wolfe R. Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial. The Lancet Diabetes & Endocrinology. 2024 Feb;12(2):98-106. doi: 10.1016/S2213-8587(23)00327-3.
This publication provides valuable insights into the impact of daily low-dose aspirin on the incidence of type 2 diabetes in healthy older adults, using data from the ASPREE randomised trial.
Bloom JE, Wong N, Nehme E, Dawson LP, Ball J, Anderson D, Cox S, Chan W, Kaye DM, Nehme Z, Stub D. Association of socioeconomic status in the incidence, quality-of-care metrics, and outcomes for patients with cardiogenic shock in a pre-hospital setting. European Heart Journal – Quality of Care & Clinical Outcomes. 2024 Jan 12;10(1):89-98. doi: 10.1093/ehjqcco/qcad010.
This publication explores the association between socioeconomic status and the incidence, quality-of-care metrics, and outcomes for patients with cardiogenic shock in a pre-hospital setting. Its findings highlight the importance of addressing socioeconomic disparities to improve the care and outcomes of high-risk patients in emergency medical settings.
Omerovic E, Petrie M, Redfors B, Fremes S, Murphy G, Marquis-Gravel G, Lansky A, Velazquez E, Perera D, Reid C, Smith J, van der Meer P, Lipsic E, Juni P, McMurray J, Bauersachs J, Køber L, Rouleau JL, Doenst T. Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9-Pragmatic Research and Innovation through Multinational Experimentation. Trials. 2024 Jan 23;25(1):80. doi: 10.1186/s13063-024-07935-y.
This publication emphasises the value of pragmatic randomised controlled trials in real-world settings, aiming to improve the external validity and applicability of clinical research. Through the PRIME-9 initiative, it fosters international collaboration, enhancing the ability to address global health challenges. FWCI: 14.85.
Ball J, Dinh DT, Brennan A, Ajani A, Clark DJ, Freeman M, Oqueli E, Hiew C, Nanayakkara S, Walton A, Shaw JA, Chan W, Reid CM, Stub D. Prevalence and outcomes of patients with SMuRF-less acute coronary syndrome undergoing percutaneous coronary intervention. Open Heart. 2024 Jun 5;11(1):e002733. doi: 10.1136/openhrt-2024-002733.
This publication is impactful as it investigates the prevalence and clinical outcomes of patients with SMuRF-less acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). By analysing real-world patient data, the study highlights potential gaps in risk stratification and treatment approaches for individuals who experience ACS without traditional risk factors.
Baldi E, Klersy C, Chan P, Elmer J, Ball J, Counts CR, Rosell Ortiz F, Fothergill R, Auricchio A, Paoli A, Karam N, McNally B, Martin-Gill C, Nehme Z, Drucker CJ, Ruiz Azpiazu JI, Mellett-Smith A, Cresta R, Scquizzato T, Jouven X, Primi R, Al-Araji R, Guyette FX, Sayre MR, Daponte Codina A, Benvenuti C, Marijon E, Savastano S; OHCA-COVID study group. The impact of COVID-19 pandemic on out-of-hospital cardiac arrest: An individual patient data meta-analysis. Resuscitation. 2024 Jan;194:110043. doi: 10.1016/j.resuscitation.2023.110043.
This publication sheds light on the significant impact of the COVID-19 pandemic on out-of-hospital cardiac arrest outcomes, using individual patient data for a comprehensive analysis. Its findings are essential for understanding the broader implications of COVID-19 on emergency medical services. FWCI: 10.63.
2023 Most Impactful Papers
Dawson LP, Nehme E, Nehme Z, Zomer E, Bloom J, Cox S, Anderson D, Stephenson M, Ball J, Zhou J, Lefkovits J, Taylor AJ, Horrigan M, Chew DP, Kaye D, Cullen L, Mihalopoulos C, Smith K, Stub D. Chest Pain Management Using Prehospital Point-of-Care Troponin and Paramedic Risk Assessment. JAMA Internal Medicine. 2023 Mar 1;183(3):203-211. doi: 10.1001/jamainternmed.2022.6409.
This study evaluates the use of prehospital point-of-care troponin testing combined with paramedic risk assessment to improve chest pain management and early diagnosis of acute coronary syndromes. Its findings have the potential to enhance emergency care efficiency, reduce hospital admissions, and improve patient outcomes. Read more about the clinical trial led by Professor Dion Stub and Dr Jocasta Ball.
Hussain SM, Newman AB, Beilin LJ, Tonkin AM, Woods RL, Neumann JT, Nelson M, Carr PR, Reid CM, Owen A, Ball J, Cicuttini FM, Tran C, Wang Y, Ernst ME, McNeil JJ. Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults. JAMA Network Open. 2023 Apr 3;6(4):e237482. doi: 10.1001/jamanetworkopen.2023.7482.
This study examined how changes in body size over time affect all-cause and cause-specific mortality in healthy older adults, providing critical insights into aging and health outcomes. Citations: 26, FWCI: 8.96.
Doherty DA, Tong SYC, Reilly J, Shrapnel J, McDonald S, Ahern S, Harris I, Tam CS, Brennan AL, Hodgson C, Wilcox L, Balagurunathan A, Butcher BE, Reid CM. Registry randomised trials: a methodological perspective. BMJ Open. 2023 Mar 1;13(3):e068057. doi: 10.1136/bmjopen-2022-068057.
This publication provides a methodological perspective on registry-based randomised trials, highlighting their potential to generate high-quality, real-world evidence with greater efficiency and potential to enhance clinical research.
FWCI: 6.20.
Bloom JE, Partovi A, Bernard S, Okyere D, Heritier S, Mahony E, Eliakundu AL, Dawson LP, Voskoboinik A, Anderson D, Ball J, Chan W, Kaye DM, Nehme Z, Stub D. Use of a novel smartphone-based application tool for enrolment and randomisation in pre-hospital clinical trials. Resuscitation. 2023 Jun;187:109787. doi: 10.1016/j.resuscitation.2023.109787.
This study showcases how a smartphone-based application can improve the speed and reliability of patient enrolment and randomisation in pre-hospital clinical trials. It highlights the potential for digital innovation to enhance emergency medical research, leading to more efficient and effective patient care.
FWCI: 7.63.
Ski CF, Cartledge S, Foldager D, Thompson DR, Fredericks S, Ekman I, Hendriks JM. Integrated care in cardiovascular disease: a statement of the Association of Cardiovascular Nursing and Allied Professions of the European Society of Cardiology. European Journal of Cardiovascular Nursing. 2023 Jul 19;22(5):e39-e46. doi: 10.1093/eurjcn/zvad009.
This study highlights the importance of integrated care in cardiovascular disease management, emphasising a multidisciplinary approach to improving patient outcomes. Its recommendations help shape best practices, improving the quality of care and patient outcomes in cardiovascular nursing and allied professions.
Citations: 23, FWCI: 9.18.
2022 Most Impactful Papers
Dawson LP, Andrew E, Stephenson M, Nehme Z, Bloom J, Cox S, Anderson D, Lefkovits J, Taylor AJ, Kaye D, Smith K, Stub D. The influence of ambulance offload time on 30-day risks of death and re-presentation for patients with chest pain. Medical Journal of Australia. 2022 Sep 5;217(5):253-259. doi: 10.5694/mja2.51613.
This publication highlights grave clinical implications of systems issues in ambulance and emergency departments, leading to ramping and its association with poorer outcomes and mortality.
Nelson MR, Polekhina G, Woods RL, Reid CM, Tonkin AM, Wolfe R, Murray AM, Kirpach B, Ernst ME, Lockery JE, Shah RC, Stocks N, Orchard SG, Zhou Z. Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial. Annals of Internal Medicine. 2022 May;175(5):761-764. doi: 10.7326/M21-3823.
The objective was to investigate the effect of aspirin cessation versus continuation on disability-free survival and other clinical outcomes in a post hoc analysis of ASPREE participants who were regularly taking aspirin before trial enrolment.
Dawson LP, Smith K, Cullen L, Nehme Z, Lefkovits J, Taylor AJ, Stub D. Care Models for Acute Chest Pain That Improve Outcomes and Efficiency: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2022 Jun 14;79(23):2333-2348. doi: 10.1016/j.jacc.2022.03.380.
This publication establishes rationale introducing novel treatment strategies laying foundation for future studies.
Talic S, Marquina C, Ofori-Asenso R, Petrova M, Liew D, Owen AJ, Lybrand S, Thomson D, Ilomaki J, Zomer E, Ademi Z. Switching, Persistence and Adherence to Statin Therapy: a Retrospective Cohort Study Using the Australian National Pharmacy Data. Cardiovascular Drugs and Therapy. 2022 Oct;36(5):867-877. doi: 10.1007/s10557-021-07199-7.
This is a large population-based study looking into compliance trajectories of statins in the general population. The study highlighted the need for ongoing research and new interventions to understand and mitigate the factors contributing to medication non-adherence and discontinuation which is currently underway.
Cartledge S, Rawstorn JC, Tran M, Ryan P, Howden EJ, Jackson A. Telehealth is here to stay but not without challenges: a consultation of cardiac rehabilitation clinicians during COVID-19 in Victoria, Australia. European Journal of Cardiovascular Nursing. 2022 Aug 29;21(6):548-558. doi: 10.1093/eurjcn/zvab118.
This world first study provided data and experiences of the swift transition of cardiac rehabilitation programs to telehealth during the COVID19 pandemic. This paper has >1200 downloads and is cited by the Canadian Agency for Drugs and Technologies in Health (2022) in a policy insight document.
2021 Most Impactful Papers
Dawson LP, Biswas S, Lefkovits J, Stub D, Burchill L, Evans SM, Reid C, Eccleston D. Characteristics and Quality of National Cardiac Registries: A Systematic Review. Circulation: Cardiovascular Quality and Outcomes. 2021 Sep;14(9):e007963. doi: 10.1161/CIRCOUTCOMES.121.007963.
One of the first studies to carefully review national cardiac registries, identifying key characteristics and opportunities for international collaboration of these invaluable resources.
Fernando H, Duong T, Huynh K, Noonan J, Shaw J, Duffy SJ, Nehme Z, Smith K, Myles PS, Meikle PJ, Peter K, Stub D. Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial. European Heart Journal. 2021 Oct 14;42(39):4025-4036. doi: 10.1093/eurheartj/ehab557.
The first trial worldwide of non-opioid use in cardiac intervention analgesia. It provided a framework and clinical rationale for the seminal AVOID 2 ambulance trial. PhD candidate and first author Dr Hima Fernando was awarded the prestigious Ralph Reader award 2021 for this work. (4 CITES (Scopus), FWCI=1.95). Read our lay summary on the Monash Faculty of Medicine, Nursing and Health Sciences newsfeed.
Bosch J, Lonn EM, Jung H, Zhu J, Liu L, Lopez-Jaramillo P, Pais P, Xavier D, Diaz R, Dagenais G, Dans A, Avezum A, Piegas LS, Parkhomenko A, Keltai K, Keltai M, Sliwa K, Held C, Peters RJG, Lewis BS, Jansky P, Yusoff K, Khunti K, Toff WD, Reid CM, Varigos J, Joseph P, Leiter LA, Yusuf S. Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study participants. European Heart Journal. 2021 Aug 17;42(31):2995-3007. doi: 10.1093/eurheartj/ehab225.
The findings from this landmark trial have demonstrated that the poly-pill approach to blood pressure and lipid lowering improves long–term outcomes with the combined benefits of blood pressure and lipid lowering in moderate risk individuals. (Citations 5 (92nd percentile); FWCI – 3.31)
Dagan M, Dinh DT, Stehli J, Zaman S, Brennan A, Tan C, Liew D, Reid CM, Stub D, Kaye DM, Lefkovits J, Duffy SJ; Victorian Cardiac Outcomes Registry. Impact of Age and Sex on Treatment and Outcomes Following Myocardial Infarction. Journal of the American College of Cardiology. 2021 Nov 9;78(19):1934-1936. doi: 10.1016/j.jacc.2021.08.057.
This paper illustrates the importance of gender disparities in cardiovascular disease management of acute cardiac care, now the focus of major national initiatives to bridge the gap.
Chow CK, Atkins ER, Hillis GS, Nelson MR, Reid CM, Schlaich MP, Hay P, Rogers K, Billot L, Burke M, Chalmers J, Neal B, Patel A, Usherwood T, Webster R, Rodgers A; QUARTET Investigators. Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. The Lancet. 2021 Sep 18;398(10305):1043-1052. doi: 10.1016/S0140-6736(21)01922-X.
These findings have demonstrated the safety and efficacy of a “quad-pill approach” to blood pressure lowering that produces highly significant reductions that increase the opportunity for global improvements in the prevention of cardiovascular disease. (Citations 5 (92nd percentile); FWCI = 3.31)