Paul Lacaze, PhD

Head, Public Health Genomics Program

Phone: +61 3 990 30745

Paul Lacaze joined Monash University in September 2015 to establish the Public Health Genomics Program with the goal of conducting research into the role of genetic data for public and population health. The program operates within the Monash School of Public Health and Preventive Medicine and is centred around genetic analyses of large-scale cohort studies, biobanks, clinical trials and clinical registries.

After completing a PhD in genomics and immunology at the University of Edinburgh, Paul spent years working in the genomics technology industry before making the move back into research to help address some of the major questions faced by the field of human genetics. This includes how to effectively convert large amounts of genomic sequence data into meaningful medical information, interpret and disclose genetic information responsibly, and integrate genetic data into medical support systems.

Paul's role at Monash involves providing scientific leadership on significant genomic opportunities associated with the ASPREE study, ASPREE Healthy Ageing Biobank and clinical registries. This involves the integration of human genetic sequence data with longitudinal phenotype and medical-outcome data across thousands of individuals in the quest for a better understanding of human health and disease. Paul has a commitment to conducting patient-focused research involving public engagement, collaboration and secure data sharing.

Some of Paul's research interests include:

Identifying areas of medical utility for human genetic data

  • the benefit of genetic information at different stages of an individual's life
  • public engagement and addressing social, legal and ethical challenges of genetic information

Genomic analyses of large cohort studies, biobanks, clinical trials and disease registries

  • exploring the role of genetics versus the environment in defining human health and disease
  • integration of DNA sequence data with longitudinal deep phenotyping and medical records

Challenging genetic determinism

  • measuring penetrance and pathogenicity of genetic variants in healthy elderly adults
  • identifying rare examples of resilience against known disease-causing genetic variants

Major projects

ASPREE-Genomics, ASPREE study and clinical trial, ASPREE Healthy Ageing Biobank

STAREE study and clinical trial

The Resilience Project

The Medical Genome Reference Bank

Monash Clinical Registries

Collaborating Partners

Kinghorn Centre for Clinical Genomics, Garvan Institute, Sydney, Australia

Icahn Institute for Genomics & Multiscale Biology at Mount Sinai, New York, USA

Genetic Medicine, Royal Melbourne Hospital, Australia

BC Platforms, Genome Data Integration Platform, Finland




Paul Lacaze joins Monash SPHPM

Monash partners with BC Platforms for data management

Mount Sinai comprehensive genetic testing panel


Link to Paul Lacaze Publications (PubMed)