Our research

Our research sees us collaborate with key relevant stakeholders, including medical professionals, policy-makers, and industry and consumers representatives, to promote sustainable, effective delivery of healthcare that meets genuine patient needs.

Key publications

Streams

Health Economics of Cardiovascular Disease and Diabetes

Lead: Associate Professor Zanfina Ademi

This program seeks clarity on the future burden of cardiovascular disease and diabetes, and how early prevention may impact morbidity and mortality. We evaluate the cost-effectiveness of novel therapeutic pathways and develop new methods for decision health modelling for early preventions, considering patient quality of life, healthcare and societal costs.

Current projects include:

  • Investigating disease-associated burdens across premature death, quality of life, healthcare and societal costs here and overseas.
  • Exploring the cost-effectiveness of new treatments for cardiovascular disease and diabetes
  • Using large datasets to monitor trends in utilisation of lipid lowering therapy in Australia
  • A cost-effectiveness analysis of the implementation of the Quality in Acute Stroke Care protocol in Australia
  • Investigating the cost-effectiveness of population genomic screening of all young adults in Australia to detect Familial Hypercholesterolaemia
  • A cost-effectiveness analysis of the implementation of a Familial Hypercholesterolaemia program in the Netherlands

Health Economics of Epilepsy

Lead: Associate Professor Zanfina Ademi

This stream of research delivers evidence to underpin sound funding decisions around epilepsy that support best care and patient quality of life while meeting societal expectations. We assess new treatment approaches and identify the most cost-effective interventions for people with epilepsy in Australia. We work closely with Monash’s Central Clinical School, the Florey institute (as part of successful Australian Epilepsy project) and the Epilepsy Foundation.

Current projects include:

  • Designing an accurate and comprehensive ‘drug resistant epilepsy’ (DRE) model that captures the burden of DRE through healthcare costs, lost productivity, premature mortality, and reduced quality of life
  • Reviewing the quality of life of, and productivity burdens experienced by patients with refractory epilepsy: before and after epilepsy surgery
  • Creating a ‘dynamic epilepsy model’ that captures the total impact and new incident cases of epilepsy, and quantifies the healthcare costs, lost productivity, premature mortality, and reduced quality of life in this cohort
    • Measuring the impact of new onset seizures on quality of life through general (EQ-5D) and epilepsy-specific (QoLIE-31) validated quality of life scales, work productivity, informal care needs through and financial toxicity of those with new onset seizures
    • Markov modelling of treatment response in a 30-year cohort study of newly diagnosed epilepsy

Health Economics of Healthy lifestyle in Preconception, Pregnancy and Postpartum

Lead: Associate Professor Zanfina Ademi

In this stream we strive to understand the cost effectiveness of promising lifestyle interventions enhancing women’s health over a lifetime horizon.

Current projects include:

  • Applying the latest modelling techniques to determine cost-effectiveness of interventions based on duration and frequency of lifestyle interventions
  • Estimating the longer-term health benefits of interventions from healthcare and societal perspectives by incorporating incidence of diabetes post-partum
  • Identifying people most likely to benefit from interventions, and informing policy-makers about realistic caps on the funding of antenatal lifestyle interventions to ensure reasonable return on investment
  • Exploring new modes of dissemination for cost-effectiveness of life style interventions

Health Economics of Women, Maternal and Child Health

Lead: Associate Professor Emily Callander

This program focuses on promoting equity and efficiency in women’s, maternal, and child health care. This research is underpinned by the use of big data, and data linkage to identify health system level factors influencing equity and efficiency; as well as economic evaluations alongside clinical trials to assess the cost-effectiveness of discrete interventions.

Current projects include:

  • The use of big data and machine learning to promote value in maternal healthcare
  • Reducing the rate of stillbirth (including the My Baby’s Movement and Safer Baby Bundle interventions)
  • Cost-effectiveness of pharmacological interventions to improve pregnancy outcomes
  • Maternal system redesign, including new models of care
  • Women’s decision-making and preferences in healthcare

Outcomes Research in Musculoskeletal Health

Lead: Professor Ilana Ackerman

In this stream of epidemiological research, we seek to lessen the societal burden of osteoarthritis, to inform health service delivery and health workforce planning. We focus on joint replacement surgery utilisation and outcomes, working closely with the Australian Orthopaedic Association National Joint Replacement Registry. Our modelling evaluates the potential cost savings associated with effective musculoskeletal interventions, including osteoarthritis management programs.

Current projects include:

  • The use of new methods to monitor the risk of revision joint replacement surgery at a population level
  • The use of patient-reported outcomes data to identify patients at risk of early revision surgery after joint replacement
  • Quantifying delay or avoidance of unwarranted knee replacement surgery after osteoarthritis management programs
  • Examining changes over time in the burden of hip, knee and hand osteoarthritis in Australia using Global Burden of Disease Study data
  • The application of productivity-adjusted life years to estimate national productivity loss associated with osteoarthritis and potential productivity gains from effective treatment