Dr Francesca Short


  • Functional Genomics
  • Pathogenesis
  • Microbiology
  • Systems Biology
  • Biocides

Francesca is an ARC DECRA fellow in the Department of Microbiology, Monash University, and a Visiting Fellow at the ARC Centre of Excellence in Synthetic Biology, Macquarie University. She completed her PhD at the University of Cambridge, and subsequently was a Sir Henry Wellcome postdoctoral fellow at the Wellcome Sanger Institute, UK, and a Senior Research Fellow at Macquarie University, Sydney. Francesca has pioneered the use of high-throughput functional genomics approaches to understand the regulation and strain-specificity of virulence in priority bacterial pathogens.

Francesca and her team use a combination of innovative functional genomics and molecular approaches to understand how Gram-negative bacteria control their behaviour, with a view to building fundamental knowledge of pathogenesis and AMR and improving our ability to predict phenotype from genotype. Her secondary research interest focuses on the mechanisms and consequences of antimicrobial biocides (such as disinfectants, sanitisers and preservatives), in particular their potential to directly antagonise some antibiotics.


  • Understanding the regulatory networks controlling virulence and antibiotic resistance in Gram-negative pathogens
  • Defining strain-specific modes of virulence control
  • Development of new functional genomics approaches
  • Molecular mechanisms of antimicrobial biocides


  • Building fundamental knowledge regarding bacterial mechanisms of pathogenesis and drug-resistance
  • Developing effective high-throughput approaches to study bacterial regulation networks
  • Discoveries enabling improved use of antimicrobial biocides in clinical and industrial settings