Dr Francesca Short


  • Functional Genomics
  • Pathogenesis
  • Microbiology
  • Systems Biology
  • Biocides

Francesca is an ARC DECRA fellow in the Department of Microbiology, Monash University, and a Visiting Fellow at the ARC Centre of Excellence in Synthetic Biology, Macquarie University. She completed her PhD at the University of Cambridge, and subsequently was a Sir Henry Wellcome postdoctoral fellow at the Wellcome Sanger Institute, UK, and a Senior Research Fellow at Macquarie University, Sydney. Francesca has pioneered the use of high-throughput functional genomics approaches to understand the regulation and strain-specificity of virulence in priority bacterial pathogens.

Francesca and her team use a combination of innovative functional genomics and molecular approaches to understand how Gram-negative bacteria control their behaviour, with a view to building fundamental knowledge of pathogenesis and AMR and improving our ability to predict phenotype from genotype. Her secondary research interest focuses on the mechanisms and consequences of


  • Understanding the regulatory networks controlling virulence and antibiotic resistance in Gram-negative pathogens
  • Defining strain-specific modes of virulence control
  • Development of new functional genomics approaches
  • Molecular mechanisms of antimicrobial biocides


  • Building fundamental knowledge regarding bacterial mechanisms of pathogenesis and drug-resistance
  • Developing effective high-throughput approaches to study bacterial regulation networks
  • Discoveries enabling improved use of antimicrobial biocides in clinical and industrial settings