Prof. Gary Egan

Gary Egan

Professor & Foundation Director, Monash Biomedical Imaging

Director, ARC Centre of Excellence for Integrative Brain Function

_

BSc (Hons) University of Melbourne

MBA (1997) Monash University

PhD (1989) University of Melbourne

_

Tel: +61 3 9902 9750

Fax: +61 3 9902 9817

Email: gary.egan@monash.edu

View profile

Biography

Gary Egan is the Foundation Director of the Monash Biomedical Imaging (MBI) research facilities and a Distinguished Professor in the Monash University Institute for Cognitive and Clinical Neurosciences. The MBI research infrastructure includes a 3 Tesla MR scanner and a simultaneous 3 Tesla MR-PET scanner for human research, and ultrahigh field 9.4 Tesla MRI and PET-CT scanners for preclinical research. The MBI facilities are located adjacent to and connected with the Australian Synchrotron Imaging and Medical Beam Line, which together are the only integrated synchrotron imaging and multi-modality (MRI/PET/SPECT) biomedical imaging research facility worldwide.

Prof Egan undertook his PhD in experimental particle physics and worked as a post-doctoral research fellow at the European Centre for Particle Physics (CERN) in Geneva, Switzerland. He was a Senior and Principal Research Fellow at the Howard Florey Institute, University of Melbourne and Associate Director and Professor in the Centre for Neuroscience, University of Melbourne from 2000 until 2010.

Prof Egan is currently the Director of the Australian Research Council Centre of Excellence for Integrative Brain Function. The Centre's research will focus on the greatest scientific challenge of the 21st Century: to understand the link between brain activity and human behaviour. To achieve this goal the Centre's research program will integrate the work of many of Australia's leading brain researchers in the fields of anatomy, physiology, neuroimaging, informatics, neural modeling and neuroengineering. The Centre has been funded by a $20 million grant from the Australian Research Council over a seven year period (2014-20).

He is lead investigator of the Victorian Biomedical Imaging Capability (Victorian Science Agenda grant, 2010-15) that funded the MRI, PET-CT and animal imaging facilities at Victorian research organisations, led by Monash University. He is the Deputy Director of the Australian National Imaging Facility (National Collaborative Research Infrastructure Scheme, Education Investment Fund and Collaborative Research Infrastructure grants, 2007-16) and node director of the Monash University node of the National Imaging Facility.

Prof Egan leads the development of advanced MRI methods to develop MR biomarkers for use in future clinical drug trials in neurodegenerative diseases. His research focuses on the development of neuroimaging biomarkers to enable identification of progressive neurodegeneration and neural dysfunction in the clinical neurosciences. His research team has also developed novel MRI techniques to quantify axonal and myelin pathology in patients with Multiple Sclerosis (MS) and animal models of MS.

He has achieved of a substantive body of published work that has made a significant impact on the neuroimaging and neuroscience fields. He has published over 230 papers in peer reviewed journals: 24 in leading particle physics journals (1990-93) resulting from his PhD and post-doctoral research; 25 papers in medical imaging research related to positron emission tomography (1995-99); and over 180 papers in neuroimaging and neuroscience. He has a Google h-index of 64 with over 11,600 citations (see http://scholar.google.com.au/citations) and a Thomson ISI H-score of 47 and over 6,300 citations to his publications.

Gary Egan has the ability to attract high-quality postgraduate students and postdoctoral fellows and has supervised 18 postgraduate and post-doctoral students, with eight completing in the past 5 years. He has sustained success in obtaining significant and substantial grants to support his research, as a chief investigator (CI) on 23 peer reviewed funded grants in the past five years ($41.4 million). Throughout his career he has been awarded a total of 19 NHMRC grants, 15 ARC grants, 2 NIH grants and 30 other grants in competitive grant applications (total received funding $51.1 million).

Affiliations and memberships

  • International Organisation for Human Brain Mapping (OHBM), USA
  • International Society for Magnetic Resonance in Medicine (ISMRM), USA
  • Australasian Neuroscience Society
  • Society for Neuroscience, USA
  • Governing Board Member, International Neuroinformatics Co-ordinating Facility (INCF) Stockholm
  • Member, International Neuroinformatics Co-ordinating Facility (INCF) Training Committee
  • Member, NHMRC Research Translation Faculty
  • Member, NHMRC Assigners Academy
  • Chairperson, Imaging and Visualisation Scientific Advisory Committee (IVSAC), Multi-modal Australian Sciences Imaging and Visualisation Environment (MASSIVE) Computational Initiative, Melbourne
  • Member & Ambassador, Club Melbourne, State Government of Victoria
  • Deputy Editor in Chief, Journal of Human Brain Mapping, Wiley Publishers
  • Member, Editorial Board, International Journal of Imaging Systems and Technology, Wiley, USA
  • Member, Editorial Board, Frontiers in Neuroinformatics, Frontiers Research Foundation, Switzerland

Recent publications

  1. A. Zalesky, H. Akhalghi, L. Corben, J. Bradshaw, M.B. Delatycki, E. Storey, N. Georgiou-Karistianis, G.F. Egan, "Cerebello-cerebral connectivity deficits in Friedreich's Ataxia", Brain Structure Function 219 (2014) 969-81.
  2. N. Georgiou-Karistianis, J.C. Stout, J.F. Dominguez, S.P. Carron, A. Ando, A. Churchyard, P. Chua, I. Bohanna, A.R. Dymowski, G. Poudel, G.F. Egan, "Functional Magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study" Human Brain Mapping 35 (2014) 1847-64.
  3. S.R. Davis, S.L. Davison, M. Gavrilescu, K. Searle, A. Gogos, S.L. Rossell, G.F. Egan, R.J. Bell, "The effects of testosterone on visuo-spatial function and verbal fluency in postmenopausal women: results from a functional magnetic resonance pilot study", Menopause 21 (2014) 410-4.
  4. S.N. Krieger, D. Ivanov, L. Huber, E. Roggenhofer, B. Sehm, R. Turner, G.F. Egan, C.J. Gauthier, "Using carbogen for calibrated fMRI at 7 Tesla: comparison of direct and modelled estimation of the M parameter", Neuroimage 84 (2014) 605-14.
  5. D.K. Thompson, K. Lee, G.F. Egan, S.K. Warfield, L.W. Doyle, P.J. Anderson, T.E. Inder, "Regional white matter microstructure in very preterm infants: predictors and 7 year outcomes", Cortex 53 (2014) 60-74.
  6. G.R. Poudel, G.F. Egan, A. Churchyard, P. Chua, J.C. Stout, N. Georgiou-Karistianis, "Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study", J. Psychiatry and Neuroscience 39 (2) (2014) 87-96.
  7. D.K. Thompson, C. Omizzolo, C. Adamson, K.J. Lee, R. Stargatt, G.F. Egan, L.W. Doyle, T.E. Inder, Peter J. Anderson, "Longitudinal growth and morphology of the hippocampus through childhood: Impact of prematurity and implications for memory and learning", Human Brain Mapping 35 (2014) 4129-39.
  8. P. Saker, F.R.M. Adib, G.F. Egan, M. McKinley, D.A. Denton, M. Farrell, "Regional brain responses associated with drinking water during thirst and after satiation", PNAS 111 (2014) 5379-84.
  9. G. Poudel, J.C. Stout, J.F. Dominguez, L. Salmon, A. Churchyard, P. Chua, N. Georgiou-Karistianis, G.F. Egan, "White matter connectivity reflects clinical and cognitive status in Huntington's disease", Neurobiology of Disease 65 (2014) 180-7.
  10. S.C. Beeman, L.A. Cullen-McEwen, M. Zhang, T. Wu, E. Baldelomar, J. Dowling, A. Ng, Q-Z. Wu, J.A Armitage, V.G. Puelles, G.F. Egan, K.M. Bennett, "MRI based glomerular morphology and pathology in whole human kidneys", Am J Physiology Renal Physiol 306 (2014) 1381-90.
  11. W. J. Goscinski, P. McIntosh, U. Felzmann, A. Maksimenko, C. Hall, T. Gureyev, D. Thompson, A. Janke, G. Galloway, N. Killeen, P. Raniga, O. Kaluza, A. Ng, G. Poudel, D. Barnes, P. Bonnington, G.F Egan, "The Multi-modal Australian ScienceS Imaging and Visualisation Environment (MASSIVE) high performance computing infrastructure: applications in neuroscience and neuroinformatics research", Frontiers in Neuroinformatics 8 (2014) 30:1-13.
  12. A. Verghese, S.C. Kolbe, A.J. Anderson, G.F. Egan, T.R. Vidyasagar, "Relationship between top-down attention, reading ability and the size of the primary visual cortex", Neuroimage 93 (2014) 47-52.
  13. B. Skiold, Q. Wu, S.B. Hooper, P.G. Davis, R. McIntyre, M. Tolcos, J. Pearson, R. Vreys, G.F. Egan, S.K. Barton, J.L.Y. Cheong, G.R. Polglase, "Early detection of ventilation induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs", PLoS One 9 (2014) e95804.
  14. M.J. Farrell, S. Koch, A, Ando, L.J Cole, G.F. Egan, S.B. Mazzone, "Functional connected brain regions in the network activated during capsaicin inhalation", Human Brain Mapping 35 (2014) 5341-55.
  15. L. Corben, S. Kashuk, H. Akhalghi, S. Jamadar, M.B. Delatycki, J. Fielding, N. Georgiou-Karistianis, B. Johnson, G.F. Egan, "Myelin paucity of the superior cerebellar peduncle in individuals with Friedreich's ataxia: an MRI magnetization transfer imaging study", Journal of Neurological Sciences 343 (2014) 138-43.
  16. S.N. Krieger, C.J. Gauthier, D. Ivanov, L. Huber, E. Roggenhofer, B. Sehm, G.F. Egan, R. Turner, "Regional reproducibility of calibrated BOLD functional MRI: implications for the study of cognitive and plasticity", Neuroimage 101 (2014) 8-20.
  17. J.F. Bertram, L.A. Cullen-McEwen, G.F. Egan, N. Gretz, E. Baldelomar, S.C. Beeman, K.M. Bennett, "Why and how we determine nephron number", Pediatric Nephrology 29 (2014) 575-80.
  18. P. Adlard, B. Tran, D. Finkelstein, P. Desmond, L. Johnston, A.I. Bush, G.F. Egan, "A review of neuroimaging of pathology in Alzheimer's disease", Frontiers in Neuroscience 8 (2014) 327.
  19. Q. Duché, P. Raniga, G.F. Egan, O. Acosta, G. Gambarota, O. Salvado, H. Saint-Jalmes, "New partial volume estimation methods for MRI MP2RAGE", Med Image Comput Comput Assist Interv. 17 (2014) 129-36.
  20. S. Jamadar, B. Johnson, G.F. Egan, J. Fielding, "Behaviour-related changes in striatal activation following ocular motor training", Frontiers in Human Neuroscience 9 (2015) 653.
  21. G.R. Poudel, J.C. Stout, M. Gray, J.F. Domínguez, L. Salmon, A. Churchyard, P. Chua, B. Borowsky, G.F. Egan, N. Georgiou-Karistianis, "Functional changes during working memory in Huntington's disease: 30 month longitudinal data from the IMAGE-HD study", Brain Structure & Function 101 (2015) 501-12.
  22. S.N. Krieger, L. Huber, B.A. Poser, R. Turner, G.F Egan, "Simultaneous acquisition of cerebral blood volume, blood flow and blood oxygenation weighted MRI signals at ultra-high magnetic field", Magnetic Resonance in Medicine 74 (2015) 513-7.
  23. G. Poudel, J.C. Stout, J.F. Dominguez, A. Churchyard, P. Chua, G.F. Egan, N. Georgiou-Karistianis, "Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study", Neurobiology of Disease 74 (2015) 406-412.
  24. K. Pawar, G.F. Egan, J. Zhang, "Multichannel compressive sensing MRI using noiselet encoding", PLoS One 10 (2015) e0126386.
  25. A. van der Walt, S.C. Kolbe, P.J. Mitchell, Y. Wang, H. Butzkueven, G.F. Egan, C. Yannikas, S. Graham, T.J. Kilpatrick, A. Klistorner, "Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis", PLoS One 10 (2015) e0121084.
  26. S. Gabery, N. Georgiou-Karistianis, S. Hult Lundh, R.Y. Cheong, J. Stout, A. Churchyard, G.F. Egan, D. Kirik, Å. Petersén, "Volumetric analysis of the hypothalamus in Huntington disease using 3T MRI: The IMAGE-HD Study", PLOS One 10 (2015) e0117593.
  27. C.E. Warner, W.C. Kwan, D. Wright, L.A. Johnston, G.F. Egan, J.A. Bourne, "The Pulvinar is implicated in preservation of vision following early life lesions of primary visual cortex", Current Biology 25 (2014) 1-11.
  28. T. Nyugen, P. Raniga, D. Barnes, G.F Egan, "Design, implementation and operation of a multi-modality research biomedical imaging informatics repository", Health Information Science and Systems 3 (2015) S6:1-10.
  29. D.K. Thompson, K.J. Lee, L. van Bijnen, A. Leemans, L. Pascoe, S.E. Scratch, J. Cheong, G.F. Egan, T.E. Inder, L.W. Doyle, P.J. Anderson, "Accelerated corpus callosum development in prematurity predicts improved outcome", Human Brain Mapping 36 (2015) 3733-48
  30. S. Jamadar, B. Johnson, M. Clough, G.F. Egan, J. Fielding, "Behavioural and neural plasticity of ocular motor control: changes in performance and fMRI activity following antisaccade training", Frontiers Hum Neurosci. 9 (2015) 653.
  31. G.R. Poudel, S. Driscoll, J.F. Domínguez D, J.C. Stout, A. Churchyard, P. Chua, G.F. Egan, N. Georgiou-Karistianis, "Functional brain correlates of neuropsychiatric function in presymptomatic Huntington's disease: The IMAGE-HD study", J Huntingtons Dis. 4 (2015) 325-32.
  32. J.F. Domínguez D, J.C. Stout, G. Poudel, L. Salmon, A. Churchyard, P. Chua, G.F. Egan, N. Georgiou-Karistianis, "Multi-modal imaging biomarkers in premanifest and early Huntington's disease: 30 month IMAGE-HD data", British Journal Psychiatry 208 (2016) 571-8. [IF 7.34]
  33. J.F. Domínguez D, A.C.L. Ng, G. Poudel, J.C, Stout, A. Churchyard, P. Chua, G.F. Egan, N. Georgiou-Karistianis, "Iron accumulation in the basal ganglia in Huntington's disease: cross-sectional data from the IMAGE-HD study", J Neurology Neurosurg Psych 87 (2016) 545-9.
  34. I.H. Harding, L.A. Corben, E. Storey, G.F. Egan, M.R. Stagnitti, G.R. Poudel, M.B. Delatycki, N. Georgiou-Karistianis, "Fronto-cerebellar dysfunctiona and discconnectivity underlying cognition in Friedreich Ataxia: The IMAGE-FRDA Study", Human Brain Mapping 37 (2016) 338-50.
  35. I.H. Harding, P. Raniga, M.B. Delatycki, M.R. Stagnitti, L.A. Corben, E. Storey, N. Georgiou-Karistianis, G.F. Egan, "Iron Accumulation and Tissue Loss in Basal Ganglia, Midbrain, Thalamus, and Dentate Nuclei in Friedreich Ataxia: The IMAGE-FRDA Study", accepted J Neurol Neurosurg Psychiatry (Feb, 2016)
  36. J.J. Maller, R.H. Thomson, A.C. Ng, C. Mann, H. Ackland, M. Eager, P.B. Fitzgerald, G.F. Egan, J.V. Rosenfeld, "Brain morphometry in blind and sighted subjects", accepted in J Clinical Neuroscience (Jan, 2016).
  37. S. Jamadar, J. Fielding, V. Calhoun, B. Johnson, G.F. Egan, "Intrinsic connectivity provides the baseline framework for individual variability in motor performance: a multivariate fusion analysis of low- and high-frequency resting-state oscillations and antisaccade performance", accepted in Brain Connectivity (April, 2016).
  38. C.R. Baker, Domínguez D J.F, Stout J., Gabery S., Churchyard A., Chua P., Egan G., Petersén A., Georgiou-Karistianis N., Poudel G.R., "Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function", Journal of the Neurological Sciences 364 (2016) 148-53.
  39. L.P. Selvadurai, I.H. Harding, L.A. Corben, M.R. Stagnitti, E. Storey, G.F. Egan, M.B. Delatycki, N. Georgiou- Karistianis, "Cerebral and cerebellar grey matter atrophy in Friedreich ataxia: the IMAGE-FRDA study", accepted subjected to revision in Journal of Neurology (June, 2016)

Current research grants

  1. NHMRC Principal Research Fellowship Grant #1003993: "Development of ultrahigh resolution brain imaging for investigating neurological and neurodegenerative diseases", G.F. Egan (2011-16)
  2. NHMRC Project Grant APP1042528, 'Activity in central cough networks in patients with cough hypersensitivity' (2013-2015) Chief Investigators: S. Mazzone, M. Farrell, G.F. Egan
  3. NHMRC Project Grant APP1046037: 'A longitudinal neuroimaging study investigating reorganisation of cerebellar-cerebral networks in Friedreich ataxia', (2013-2016) Chief Investigators: N Georgiou-Karistianis, G.F. Egan, M. Delatycki, A. Churchyard, L. Corben
  4. NHMRC Project APP1042893: 'A role for the pulvinar nucleus in visual cortical development and plasticity' (2013-15) Chief Investigators: J. Bourne, D. Leopold, G.F. Egan
  5. NHMRC Project Grant APP1061291: "Development of folding in the fetal cerebral cortex", (2014-16) Chief Investigators: DW Walker, J Britto, L Johnston, M Tolcos, G.F. Egan
  6. NHMRC Project Grant APP1086188, "ASPREE NEURO Study: Cerebral micro-haemorrhages and aspirin in the elderly: cognitive and clinical consequences. A prospective randomised controlled trial" (2015-2018) Chief Investigators: J. McNeil, G.F. Egan, A. Brodtmann, S. Ward, N. Ferris, M. Bailey
  7. ARC Centre of Excellence CE140100007: "ARC Centre of Excellence for Integrative Brain Function", (2014-20) CIs: G.F. Egan, M. Rosa, J. Mattingley, P. Robinson, P. Sah, G. Stuart, M. Ibbotson, A. Lowery, E. Arabzadeh, G. Paxinos, P. Martin, S. Petrou, U. Grunert, E. Skafidis, M. Garrido; PIs - M. Breakspear, P. Mitra, J. Victor, T. Margrie, M. Diamond, G. Johnson, D. Leopold, J. Movshon, H. Markram, S. Hill.
  8. National Collaborative Research Infrastructure Scheme (NCRIS) "Support for the National Imaging Facility", (2015-16) Co-Principal Investigators – G. Galloway, G.F. Egan, et al.