FLECT-CT (MIPS)

TriFoil FLECT and Mediso CT Small Animal Imaging System

The TriFoil FLECT and Mediso CT small animal imaging system is located at the Monash Institute for Pharmaceutical Sciences (MIPS - Parkville). The FLECT and CT instruments provide in vivo optical imaging with uniform sensitivity and resolution throughout the object. The system provides images of deep tissue phenomena without loss of image quality or quantitative accuracy. The X-ray CT scanner provides co-registered images for anatomical correlation that significantly improve the segmentation and resolution of the optical images.

The system is capable of imaging rodent animal models with axial and transaxial fields of view of 38mm and 100mm (mice), and 42 frequency excitation options, up to 16 light filtration options, and is configured with 'InVivoScope' control and analysis software.

  • FLECT system capable of imaging in the range of ~500-870 nm
  • Individualised animal tissue heterogeneity map for compensation/ correction of attenuation of photons based on CT image
  • Deep tissue algorithms for fluorescence recovery based on individualised geometry of each animal
  • Ability to use plug-in imaging cells compatible with MRI, and to fuse FLECT, CT and MRI images

InSyTe FLECT/CT Publication List

This list incorporates all publications using FLECT technology (current as of April 2019):

Guilleminault et al., Journal of Controlled Release 2014; 196:344-354
Fate of inhaled monoclonal antibodies after the deposition of aerosolized particles in the respiratory system
https://doi.org/10.1016/j.jconrel.2014.10.003

Htun et al., Nat. Comm. 2017; 8(75):1-16
Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques
https://doi.org/10.1038/s41467-017-00138-x

Lim et al., Theranostics 2017; 7(5):1047-1061
A unique recombinant fluoroprobe targeting activated platelets allows in vivo detection of arterial thrombosis and pulmonary embolism using a novel three-dimensional fluorescence emission computed tomography (FLECT) technology
https://doi.org/10.7150/thno.18099

Yap et al., Theranostics 2017; 7(10):2565- 2574
Targeting activated platelets: a unique and potentially universal approach for cancer imaging
https://doi.org/10.7150/thno.19900

Lisitskiy et al., Bioorg. Med. Chem. Lett. 2017; 27(16):3925-3930
Multifunctional human serum albumin-therapeutic nucleotide conjugate with redox and pH-sensitive drug release mechanism for cancer theranostics
https://doi.org/10.1016/j.bmcl.2017.05.084

Popova et al., Bioorg. Med. Chem. Lett. 2018; 28(3):260-264
Biotin-decorated anti-cancer nucleotide theranostic conjugate of human serum albumin: Where the seed meets the soil?
https://doi.org/10.1016/j.bmcl.2017.12.061

Sun et al., Biomaterials 2018; 183:268-279
A targeting theranostics nanomedicine as an alternative approach for hyperthermia perfusion
https://doi.org/10.1016/j.biomaterials.2018.04.016

Hu et al., J. Mater. Chem. B, 2018, 6:6122-6132
Targeted dual-mode imaging and phototherapy of tumors using ICG-loaded multifunctional MWCNTs as a versatile platform
https://doi.org/10.1039/c8tb01870g