This small animal PET-CT scanner is located at the Alfred Research Alliance-Monash Biomedical Imaging (ARA-MBI) site in Prahran.
The Mediso NanoPET/CT is a small animal preclinical scanner suitable for a wide variety of radioactive tracer imaging and computer tomography (CT). Typical applications for PET tracers include oncology, cardiology, metabolic, neurodegeneration and obesity research. The CT component is ideally suited to a number of applications including bone, organ, anatomy and developmental biology research.
Benefits of PET-CT
High sensitivity and resolution; increasing signal to noise, reducing radiation exposure and scan times – ultimately reducing study numbers and enabling multiple scans in the same animal
Multi-bed increases throughput and ensures efficient use of radioligands
Combined PET/CT enables precision anatomical localisation of radiotracer without requirement for MRI (dependent on application)
Physiologically gated acquisitions for optimal in-vivo lung imaging
Can be flexibly configured to acquire PET/CT, PET or CT
>1mm FWHM PET resolution
>10um CT resolution
Optimised for low dose radiotracer/X-ray acquisitions enabling longitudinal in-vivo studies
Whole animal PET/CT (300mmx125x125mm)
Wide range of molecular imaging and computed tomography applications for studies of animal models of health and disease, drug discovery and toxicology
Bench to bedside and back again translational applications
Receptor/enzyme/transporter mapping, evaluation of metabolism, glucose metabolism, drug receptor occupancy/kinetics, molecular/anatomical biomarkers for disease aetiology, ontology, prognosis, therapeutic efficacy, patient segregation etc
High-resolution anatomical assessment of both soft and hard tissue in vivo, post-mortem, surgical resections/biopsies
PET-CT technical specifications
16cm gantry bore to accommodate imaging of mice, rats and rabbits with interchangeable beds and radiation shields
Low dose CT protocols (<50mGy for a three minute scan) are compatible with longitudinal rodent studies
Imaging beds provide integrated animal support, with gas anaesthesia and controlled heating and monitoring
Open access system with a one-step animal loading procedure and single motion PET and CT acquisition to enable automatic fusion of PET and CT images
Reconstructed PET resolution is 1mm and CT resolution is down to 10 micron
Axial scanning up to 300mm and transaxial scanning up to 125mm
Up to four mice can be imaged simultaneously with the four-animal bed
VivoQuant software for analysis is available in the PET/CT room
Isoflurane anaesthesia and necessary physiological monitoring (temperature, respiration, heart rate)
On-site radio-HPLC for radiometabolite and kinetic modelling analyses
Hidex AMG Gamma counter for nuclear medicine and PET applications, featuring an onboard balance and 250 sample capacity
We have a team of highly experienced imaging staff that can assist with all aspects of your study, from study design and protocol development through to image analysis and manuscript preparation.
Bookings are made via iLab, as per standard Monash Biomedical Imaging booking protocols
Users need to liaise with Monash Biomedical Imaging to obtain access to the scanner, animal holding and radiopharmacy rooms, and regarding ARA-MBI-specific training/OHS requirements. Please email firstname.lastname@example.org
Users should note requirement for radiation safety training and individual user radiation licence (Dept of Health) before use of radiopharmaceuticals can commence.