Fielding/White group

Ocular Motor Research group

Key terms

Human Behaviour, Human System Disorders, MRI Techniques, Multiple Sclerosis, Neurocognitive Processes, Neuroimaging, Ocular Motor System.

Research Overview

The group’s research entails an investigation of the ocular motor system as a means of developing an understanding of neurocognitive processes fundamental to normal human behaviour, and how these processes may be, or become, dysfunctional. The work combines a range of sophisticated approaches (ocular motor, neuropsychological and neuroimaging), and primarily explores (dys) function in human lesion and system disorders. Establishing the clinical utility of ocular motor measures is a primary goal of the research, translating research outcomes into clinical practice.

This entails developing and applying methods that can:

  • sensitively measure disease severity and evolution
  • evaluate the efficacy of treatment
  • advance our understanding of the neurobiological bases of phenotypically similar conditions.

Projects

Current Project Funding

  • 2017-21 Ocular motor assessment as an extension of the neurological examination in multiple sclerosis
    Chief Investigators:Fielding, J
    Funding Source:Genzyme Corporation
    Funding Amount:$ 668,545
  • 2015-19 Correlation of structure and function in the brain in Multiple Sclerosis: is fingolimod neuroprotective?
    Chief Investigators:  White, O., Fielding, J.
    Funding Source:Novartis
    Funding Amount:$476,722
  • 2016-20 Correlation of structure and function in multiple sclerosis
    Chief Investigators:  White, O., Fielding, J. Clough, M.
    Funding Source:Cabrini Foundation Clinical Research Grant
    Funding Amount:$29,830.00

Available student research projects

Selected Recent Publications

See Pubmed search for most recent publications: Fielding J + Monash

  • Shelton, A., Cornish, K., Godler, D., Bui, M., Kolbe, S., & Fielding, J. (2017). White matter microstructure, cognition and molecular markers in Fragile X premutation females. Neurology, 88(22):2080-2088
  • Shelton, A., Cornish, K., Kolbe, S., Clough, M., Slater, H.., Xin, L., Kraan, K., Bui, M., Godler, D., & Fielding, J. (2016) Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females. Translational Psychiatry, 6, e984
  • Johnson, B., Lum, J., Rinehart, N. & Fielding, J. (2016). Ocular motor disturbances in autism spectrum disorders: systematic review and comprehensive meta-analysis. Neuroscience & Biobehavioral Reviews, 69:260-79
  • Fielding, J., Clough, M., Millist, L., Beh, S., Sears D., Frohman, A., Renneker, R., Lim, J., Lizak, N., Frohman, T., White, O., & Frohman, E. (2015). Ocular motor pathophysiological signatures of cognitive dysfunction in multiple sclerosis. Nature Reviews Neurology, 11, 637–645
  • Clough, M., Millist, L., Lizak, N., Frohman, T., Frohman, E., White, O., & Fielding, J. (2015). Ocular motor measures of cognitive dysfunction in Multiple Sclerosis II: Inhibitory control. Journal of Neurology, 262(5):1130-7.
  • Clough, M., Mitchell, L., Millist, L., Lizak, N., Frohman, T., Frohman, E., White, O., & Fielding, J. (2015). Ocular motor measures of cognitive dysfunction in Multiple Sclerosis II: Working memory. Journal of Neurology, 262(5):1138-47.