Fielding/White group

Ocular Motor Research group

Key terms

Human Behaviour, Human System Disorders, MRI Techniques, Multiple Sclerosis, Neurocognitive Processes, Neuroimaging, Ocular Motor System.

The group

2019 Fielding-White group. L-R: Ms Elisha Papdemitriou, Ms Paige Foletta, Dr Hue Mun Au Yong, Prof Owen White, Ms Sylvia Dymmock, Ms Georgia Fuller Symons, Ms Emma Solly, A/Prof Joanne White, Dr Meaghan Clough, Dr Wendy Wang.

Meet the team

Research Overview

The group’s research entails an investigation of the ocular motor system as a means of developing an understanding of neurocognitive processes fundamental to normal human behaviour, and how these processes may be, or become, dysfunctional. The work combines a range of sophisticated approaches (ocular motor, neuropsychological and neuroimaging), and primarily explores (dys) function in human lesion and system disorders. Establishing the clinical utility of ocular motor measures is a primary goal of the research, translating research outcomes into clinical practice.

This entails developing and applying methods that can:

• sensitively measure disease severity and evolution
• evaluate the efficacy of treatment
• advance our understanding of the neurobiological bases of phenotypically similar conditions.

News updates

• Visual snow causes being revealed
  • Plain language summary
  • Video
• $140,000 donation kicks off research into Visual Snow
• Visual snow: understanding the neurological condition

Projects

Current Project Funding

• 2019 Elucidating the neuropathophysiology of visual snow
  Chief Investigators: Fielding, J & White, O.
  Funding Source: Visual Snow Initiative
  Funding amount; $140,267
• 2017-21 Ocular motor assessment as an extension of the neurological examination in multiple sclerosis
  Chief Investigators:Fielding, J
  Funding Source:Genzyme Corporation
  Funding Amount:$ 668,545
• 2015-19 Correlation of structure and function in the brain in Multiple Sclerosis: is fingolimod neuroprotective?
  Chief Investigators:  White, O., Fielding, J.
  Funding Source:Novartis
  Funding Amount:$476,722
• 2016-20 Correlation of structure and function in multiple sclerosis
  Chief Investigators:  White, O., Fielding, J. Clough, M.
  Funding Source:Cabrini Foundation Clinical Research Grant
  Funding Amount:$29,830.00

Available student research projects

• Motor proficiency and attentional control in Autism spectrum disorder

Selected Recent Publications

See recent publications for Jo Fielding in the Monash RSS feed immediately below, at PubMed Fielding J + Monash and select list further down.

• Ternes, A-M., Clough, M, Foletta, P., White, O., & Fielding, J. (2019). Characterisation of inhibitory failure in Multiple Sclerosis: Evidence of impaired conflict resolution. Journal of Clinical and Experimental Neuropsychology, 41(3):320-329.
• Lindor, E., Rinehart, N., & Fielding, J. (2019). Distractor inhibition in autism spectrum disorder: evidence of a selective impairment for individuals with co-occurring motor difficulties. Journal of Autism and Developmental Disorders, 49(2):669-682.
• Lindor, E., Rinehart, N., & Fielding, J. (2018). Superior visual search and crowding abilities are not characteristic of all individuals on the autism spectrum. Journal of Autism and Developmental Disorders, 48(10):3499-3512.
• White, O, McKendrick, A, & Fielding, J. (2018). Visual snow - visual misperception. Journal of Neuro-Ophthalmology, 38(4):514-521.
• Clough, M., Frohman, A., Sears, D., Foletta, P., White, O., & Fielding, J. (2018). Multiple sclerosis: Executive dysfunction, task switching and the role of attention. Multiple Sclerosis Journal: Experimental, Translational and Clinical. 4(2)
• Clough, M., Mutimer, S., Wright, D., Tsang, A., Costello, D., Gardner, A., Stanwell. P., Sun, M., Brady, R., McDonald, S., Webster, K., Johnstone, M., Semple, B., White, O., Frayne, R., Fielding, J., O’Brien, T., & Shultz, S. (2018). Ocular motor, neuropsychological, and multimodal MRI outcomes in amateur Australian rules footballers with a history of sports-related concussion. Journal of Neurotrauma. 35(5):730-738.
• Ginsberg, E., Rinehart, R., & Fielding, J. (2017) Measures of task demand and error analysis in the Corsi block–tapping test. Psychology and Neuroscience. 10(4):404-413
• McKendrick, A., Chan, J., Tien, M., Millist, L., Clough, M., Mack, H., Fielding, J., & White, O. (2017). Behavioural measures of cortical hyperexcitability assessed in people who experience visual snow. Neurology, 88(13):1243-1249.
• Shelton, A., Cornish, K., Clough, M., Gajamange, S., Kolbe, S., & Fielding, J. (2017). Disassociation between brain activation and executive function in Fragile X premutation females, Human Brain Mapping, 38(2):1056-1067
• Shelton, A., Cornish, K., Godler, D., Bui, M., Kolbe, S., & Fielding, J. (2017). White matter microstructure, cognition and molecular markers in Fragile X premutation females. Neurology, 88(22):2080-2088
• Shelton, A., Cornish, K., Kolbe, S., Clough, M., Slater, H.., Xin, L., Kraan, K., Bui, M., Godler, D., & Fielding, J. (2016) Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females. Translational Psychiatry, 6, e984
• Johnson, B., Lum, J., Rinehart, N. & Fielding, J. (2016). Ocular motor disturbances in autism spectrum disorders: systematic review and comprehensive meta-analysis. Neuroscience & Biobehavioral Reviews, 69:260-79
• Fielding, J., Clough, M., Millist, L., Beh, S., Sears D., Frohman, A., Renneker, R., Lim, J., Lizak, N., Frohman, T., White, O., & Frohman, E. (2015). Ocular motor pathophysiological signatures of cognitive dysfunction in multiple sclerosis. Nature Reviews Neurology, 11, 637–645
• Clough, M., Millist, L., Lizak, N., Frohman, T., Frohman, E., White, O., & Fielding, J. (2015). Ocular motor measures of cognitive dysfunction in Multiple Sclerosis II: Inhibitory control. Journal of Neurology, 262(5):1130-7.
• Clough, M., Mitchell, L., Millist, L., Lizak, N., Frohman, T., Frohman, E., White, O., & Fielding, J. (2015). Ocular motor measures of cognitive dysfunction in Multiple Sclerosis II: Working memory. Journal of Neurology, 262(5):1138-47.