Publication highlights

Below are a selection of some of published studies reflecting our high impact work. A full list of our publications can be found here

Enhancing Drug Response Prediction in Epilepsy with Emerging Multimodal Models: Focus on Clinical, Pharmacologic, and Genomic Factors. CNS Drugs May 2026
A Anderson, RSK Chang, M Howard, Z Chen, D Nhu, Z Ge, P Kwan

Prognosis of people with focal epilepsy treated with anti-seizure medications (ASMs): a narrative review of current evidence and future directions
BMJ Neurol Open, Dec 2025 S Barnard, E Foster, P Kwan, JA French, TJ O’Brien

Continuous learning as a threat to care
Health and Technology, Nov 2025 R Sparrow, Z Daus, M Howard, J Hatherley, P Kwan

Integrative deep learning of genomic and clinical data for predicting treatment response in newly diagnosed epilepsy Neurology
Nov 2025 W Feng, D Nhu, A Anderson, D Thom, S N Barnard, R Zeibich, E Foster, M Howard, S T Bellows, R Burgess, S F Berkovic, T J O’Brien, Z Chen, J French, P Kwan, Z Ge

Development and validation of clinico-imaging machine learning and deep learning models to predict responses to initial antiseizure medications in epilepsy
Epilepsia Oct 2025 M-R Nazem-Zadeh, R S-K Chang, S Barnard, H R Pardoe, R Kuzniecky, D Mishra, H Kamkar, D Nhu, D Metha, D Thom, Z Chen, Z Ge, T J O’Brien, B Sinclair, J French, M Law, P Kwan

Neuroimaging abnormalities in functional/dissociative seizures: a meta-analysis
Neurosci Biobehav Rev, Oct 2025 M Homayoun, A P-K Lo, B Sinclair, M-R Nazem-Zadeh, A Neal, T Winton-Brown, P Kwan, R A Kanaan

Self-completed patient-reported outcome measures in adults with epilepsy: a review
Epilepsia Open Nov 2025 A L Conquest, T J O’Brien, P Kwan, J A French, C B Malpas, E C Foster

AI-assisted anti-seizure medication selection: a qualitative study of the views of neurologists and epilepsy patients.
Epilepsy Behav Nov 2025 S Reeder, M Howard, R Sparrow, E Foster, Z Ge, P Kwan

Electrical stimulation of stem cell–derived human neural networks for evaluating  anti-seizure medications. Epilepsia Jul 2025. J Nicholls, J Gu, Z Chen, Z Liu, A Antonic-Baker, M S Javaid, E Moore, H Zhu, A Altalhi, D K Wright, H Sumer, T J O'Brien, P Kwan, B Rollo

Identification of dysregulated transcription factor activity in temporal lobe epilepsy. medRxiv Apr 2025. R Zeibich, T J O'Brien, P Perucca, P Kwan, A Anderson

Do the third-generation antiseizure medications provide the “magic bullet” for drug-resistant epilepsy? Focus on cenobamate. Epilepsia Mar 2025. P Kwan, M J Brodie

Association of Localizing 18 F-FDG-PET Hypometabolism and Outcome Following Epilepsy Surgery. Neurology May 2024 Merran R Courtney, Ana Antonic-Baker, Zhibin Chen, Benjamin Sinclair, John-Paul Nicolo, Andrew Neal, Cassandra Marotta, Jacob Bunyamin, Meng Law, Patrick Kwan, Terence J O'Brien, Lucy Vivash

Serial correlation between saliva and blood beta-hydroxybutyrate levels in children commencing the ketogenic diet for epilepsy. Epilepsia May 2025. N Kaul, J Duan, D Cui, M Erlichster, Z Chen, D Anderson, J Chan, I E Scheffer, E Skafidas, J Liao, P Kwan

Identification and enrichment of potential pathways in the buffy coat of patients with DRE using non-targeted metabolomics integrated with GEO Datasets. Eur J Med Res Apr 2025. H Zhu, S Zheng, L Xie, Y Yun, P Kwan, B Rollo, H Huang

Personalised selection of medication for newly diagnosed adult epilepsy: study protocol of a first-in-class, double-blind, randomised controlled trial. BMJ Open Apr 2025. D Thom, R S-K Chang, N A Lannin, Z Ademi, Z Ge, D Reutens, T O'Brien, W D'Souza, P Perucca, S Reeder , A Nikpour, C Wong, M Kiley, J-L Saw, J-P Nicolo, U Seneviratne, P Carney, D Jones, E Somerville, C Stapleton, E Foster, L Vadlamudi, D N Vaughan, J Lee, T Farrar, M Howard, R Sparrow, Z Chen, P Kwan

Validation of the Seizure-Related Impact Assessment Scale (SERIAS): a study protocol. BMJ Open Jun 2024. E Foster, A Conquest, C Ewart, J-P Nicolo, G Rayner, T Winton-Brown, T J O'Brien, P Kwan, C Malpas,  J A French

Australian Headache Epidemiology Data (AHEAD): a pilot study to assess sampling and engagement methodology for a nationwide population-based survey. J Hea dache Pain May 2024. E Foster, Z Chen, C E Wakefield, Z Ademi, E Hutton, T J Steiner, A S Zagami

Generation of a stably transfected mouse embryonic stem cell line for inducible differentiation to excitatory neurons. Experimental Cell Research, February 2024 J Gu, B Rollo, G Berecki, S Petrou, P Kwan, H Sumer, B Cromer

Role of machine learning in the management of epilepsy: a systematic review protocol. BMJ open, January 2024 RS Chang, S Nguyen, Z Chen, E Foster, P Kwan

Applications for Deep Learning in Epilepsy Genetic Research. Int J Mol Sci, September 2023 Zeibich R, Kwan P, J O'Brien T, Perucca P, Ge Z, Anderson A

Sleep and respiratory abnormalities in adults with developmental and epileptic encephalopathies using polysomnography and video-EEG monitoring. Epilepsia Open, September 2023 Sivathamboo, S., Myers, K. A., Pattichis, A., White, E. J., Ku, K. N., O'Brien, T. J., Perucca, P. & Kwan, P.

Experience of waiting for seizure freedom and perception of machine learning technologies to support treatment decision: A qualitative study in adults with recent onset epilepsy. Epilepsy Research, February 2023 Reeder S, Foster E, Vishwanath S, Kwan P

Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells. Cells, December 2022 Javaid MS, Tan T, Dvir N, Anderson A, J O'Brien T, Kwan P, Antonic-Baker A.

Modified low ratio ketogenic therapy in the treatment of adults with super-refractory status epilepticus. Parenteral and Enteral Nutrition, November 2022 Kaul, N., Nation, J., Laing, J., Nicolo, J-P., Deane, A. M., Udy, A. A., Kwan, P. & O'Brien, T. J

Preferences and user experiences of wearable devices in epilepsy: a systematic review and mixed-methods synthesis. Neurology. September 2022 S Sivathamboo, D Nhu, L Piccenna, A Yang, A Antonic-Baker, S Vishwanath, M Todaro, L W Yap, L Kuhlmann, W Cheng, J O'Brien T, N A Lannin, P Kwan

Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study. Journal of Molecular Graphics and Modelling, May 2022 Javaid, M. S., Antonic-Baker, A., Pitsillou, E., Liang, J., French, C., Hung, A., O'Brien, T. J., Kwan, P., Karagiannis, T. C. & Anderson, A.

Markov modelling of treatment response in a 30-year cohort study of newly diagnosed epilepsy. Brain May 2022 Simpson, H. D., Foster, E., Ademi, Z., Lawn, N., Brodie, M. J., Chen, Z. & Kwan, P.