Kwan group

Epilepsy and Personalised Medicine

Our work | Our people | Our news| Publication highlights

The Kwan Group undertakes highly multidisciplinary translational research that covers a broad spectrum of areas in relation to epilepsy. We are interested in improving treatment outcomes by changing the conventional ‘one-size-fits-all’ approach used in managing epilepsy to a more individualised, personalised paradigm.

We are committed to promoting the translation of research findings into clinical practice through engaging consumers and clinicians widely in our research, and understanding the economic, ethical and legal ramifications of therapeutic interventions.

Research study

For epilepsy, it’s PERSONAL

For the first time Australian patients are being prescribed AI-informed epilepsy medication as part of a nationwide, multicentre randomised control trial led by neurologist Professor Patrick Kwan.

Find out more

Our work

Our group’s translational research covers a broad spectrum of areas in relation to epilepsy - ranging from basic discovery to clinical implementation. We use innovative approaches to achieve our goal - pharmacogenomics, stem cells models, point of care diagnostic tools and machine learning models (including genetic, EEG, ECG, video and neuroimaging data) to identify new approaches to improve the outcomes and even prevent the development of epilepsy.

Our work focuses on three major research themes:

Honours and Postgraduate research projects

Highlighted research studies and trials

Our people

Kwan lab
2024 Kwan group.

Whether you want to be involved in our research, study with us, collaborate with us or donate to our work, we would be delighted to hear from you.

Email us – kwangroup@monash.edu

Group Leader

Leave this here so that Accordion nested does not detect this CT as not existing.

Principal Investigators

Leave this here so that Accordion nested does not detect this CT as not existing.

Our news

Research highlights

In the media

Saliva Matches Blood in Keto Diet Epilepsy Management
A simple saliva test could transform the lives of millions of children and adults worldwide who are on the keto diet to manage their epilepsy, and who currently endure uncomfortable finger prick tests. Read article.

Publication highlights

Below are a selection of some of published studies reflecting our high impact work. A full list of our publications can be found here

Validation of the Seizure-Related Impact Assessment Scale (SERIAS): a study protocol. BMJ Open Jun 2024. E Foster, A Conquest, C Ewart, J-P Nicolo, G Rayner, T Winton-Brown, T J O'Brien, P Kwan, C Malpas,  J A French

Australian Headache Epidemiology Data (AHEAD): a pilot study to assess sampling and engagement methodology for a nationwide population-based surveyJ Hea dache Pain May 2024. E Foster, Z Chen, C E Wakefield, Z Ademi, E Hutton, T J Steiner, A S Zagami

Generation of a stably transfected mouse embryonic stem cell line for inducible differentiation to excitatory neurons. Experimental Cell Research, February 2024 J Gu, B Rollo, G Berecki, S Petrou, P Kwan, H Sumer, B Cromer

Role of machine learning in the management of epilepsy: a systematic review protocol. BMJ open, January 2024 RS Chang, S Nguyen, Z Chen, E Foster, P Kwan

Applications for Deep Learning in Epilepsy Genetic Research. Int J Mol Sci, September 2023 Zeibich R, Kwan P, J O'Brien T, Perucca P, Ge Z, Anderson A

Sleep and respiratory abnormalities in adults with developmental and epileptic encephalopathies using polysomnography and video-EEG monitoring. Epilepsia Open, September 2023 Sivathamboo, S., Myers, K. A., Pattichis, A., White, E. J., Ku, K. N., O'Brien, T. J., Perucca, P. & Kwan, P.

Experience of waiting for seizure freedom and perception of machine learning technologies to support treatment decision: A qualitative study in adults with recent onset epilepsy. Epilepsy Research, February 2023 Reeder S, Foster E, Vishwanath S, Kwan P

Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells. Cells, December 2022 Javaid MS, Tan T, Dvir N, Anderson A, J O'Brien T, Kwan P, Antonic-Baker A.

Modified low ratio ketogenic therapy in the treatment of adults with super-refractory status epilepticus. Parenteral and Enteral Nutrition, November 2022 Kaul, N., Nation, J., Laing, J., Nicolo, J-P., Deane, A. M., Udy, A. A., Kwan, P. & O'Brien, T. J

Preferences and user experiences of wearable devices in epilepsy: a systematic review and mixed-methods synthesis. Neurology. September 2022 S Sivathamboo, D Nhu, L Piccenna, A Yang, A Antonic-Baker, S Vishwanath, M Todaro, L W Yap, L Kuhlmann, W Cheng, J O'Brien T, N A Lannin, P Kwan

Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study. Journal of Molecular Graphics and Modelling, May 2022 Javaid, M. S., Antonic-Baker, A., Pitsillou, E., Liang, J., French, C., Hung, A., O'Brien, T. J., Kwan, P., Karagiannis, T. C. & Anderson, A.

Markov modelling of treatment response in a 30-year cohort study of newly diagnosed epilepsy. Brain May 2022 Simpson, H. D., Foster, E., Ademi, Z., Lawn, N., Brodie, M. J., Chen, Z. & Kwan, P.