Cloud group
Cloud Group
Acute stroke care and treatments
We develop new stroke treatments for acute stroke care and novel treatments to aid stroke recovery.
We do this by conducting randomized controlled trials of new treatments for acute stroke care, secondary prevention of stroke and novel treatments to improve stroke recovery.
We also participate in the National Stroke Registry (AuSCR) which informs national stroke service quality improvement in stroke care.
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Group Leader
Current Trials
| Name of Trial | Type of trial |
|---|---|
| Modafinil In Debilitating Fatigue After Stroke 2 (MIDAS 2) | Phase III Randomised, double blind Clinical Trial |
| Trial of EXenatide in Acute Ischaemic Stroke (TEXAIS) | Phase II Randomised, open-label clinical trial |
| Stopping Haemorrhage With Tranexamic Acid cOmmenced Prehospital - in a Mobile Stroke Unit (STOP-MSU) | Randomised Clinical Trial |
| Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM) | Phase III Randomised, double blind Clinical Trial |
| Phase II Randomised Controlled Trial | |
| Interventional | |
| Randomised controlled clinical trial - Interventional | |
Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) | Phase III Randomised Controlled Trial |
Project
A network of sites and ‘up-skilled’ therapists to deliver best practice stroke rehabilitation of the upper limb
This NHMRC Partnership project includes clinicians, health providers, consumers, researchers and academics, who aim to increase access to best-practice stroke rehabilitation of the arm and thus achieve better outcomes for people who experience a stroke. We will employ knowledge transfer methods to change clinician behaviour and create a network of sites and ‘up-skilled’ therapists to deliver best-practice rehabilitation. Effective therapies are available to improve hand function. However, our recent national survey found that stroke survivors who experience loss of touch sensation and impaired hand function are not currently receiving recommended best-practice therapy. We developed a ‘knowledge transfer’ intervention to target this evidence-practice gap and the unmet rehabilitation needs of survivors. The intervention is guided by the Theoretical Domains Framework and Behaviour Change Wheel. It targets the delivery of science-based rehabilitation that requires specific knowledge and skill of the therapist; an application of knowledge translation that is virtually untested in our field. We will use a pragmatic before-after design to test the effectiveness of our knowledge transfer intervention to change clinician behaviour and improve outcomes. We will investigate current-generalist and specialist modes of delivery as well as cost-effectiveness. The implementation intervention will be an exemplar for translating recommended science-based rehabilitation interventions to the clinic and community. The project will deliver a knowledge translation hub, specialist delivery clinics, and a community of up-skilled therapists embedded in a range of healthcare settings. Together we will establish an allied health network across Australia for translational activities in stroke rehabilitation and establish and measure the potential benefits of a ‘new’ translational approach, which can be used to introduce other new therapeutic programs as translational activities in the future.
Current project funding
- 2017-20 NHMRC Partnership Grant APP1134495 A network of sites and ‘up-skilled’ therapists to deliver best practice stroke rehabilitation of the upper limb.
Selected recent publications
See most recent PubMed listed publications. The feed below is from Prof Cloud's Monash profile.