Jones group

Epilepsy and behaviour research group

Key terms

Epilepsy, Stress, Behavior, Cognition, Schizophrenia, Animal models, translational medical research

Jones lab
2018 Jones group. L-R: Associate Professor Nigel Jones (group leader), Ms Gabi Dezsi, Dr Ezgi Ozturk, Ms Flavia Gomez , Dr Shije Liu, Ms Elysia Sokolenko, Dr Matt Hudson, Mr Shaeng Lin, Ms Florence Le, Dr Idrish Ali, Ms Juliana Silva. Absent: Ms Veronica Woo, Mr Hattapark Dejakaisaya.

Research Goal

To explore relationships between epilepsy and its psychiatric comorbidities, and to develop disease-modifying therapies targeting underlying biological mechanisms

Research Overview

Our research utilises basic science approaches to explore animal behaviour in the context of health and disease. The primary goal of the lab is to understand the pathophysiological mechanisms which cause neurological and neuropsychiatric disorders, particularly epilepsy, cognitive disorders and mental health conditions. We employ of a range of advanced behavioural tests of cognition, anxiety, and depression, coupled with in vivo electrophysiology, molecular biology, in vivo imaging, opto/chemogenetic, immunocytochemical and transgenic methods to achieve this goal. We also study the role and influence of neuronal oscillations in cognitive behaviours in physiological circumstances, using sophisticated behavioural tasks and high-end electrophysiological recordings.

Projects

Publications

Recent publications can be seen at Pubmed search [Jones NC author ID 29394413]

  • Shultz SR, Wright DK, Zheng P, Stuchbery R, Liu S, Sashindranath M, Medcalf RL, Johnston L, Hovens CM, Jones NC, O’Brien TJ. Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury. Brain,v.138:1297-313, 2015.
  • M Yang, E Ozturk, MR Salzberg, S Rees, M Morris, TJ O’Brien, NC Jones. Environmental enrichment delays limbic epileptogenesis and restricts pathological synaptic plasticity. Epilepsia v.57(3), p:484-94. 2016.
  • M Hudson, G Rind, TJ O’Brien, NC Jones. Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine. Translational Psychiatry, v.6, e784. 2016
  • SJ Liu, P Zheng, DK Wright, G Dezsi, E Braine, T Nguyen, NM Corcoran, LA Johnston, CM Hovens, JN Mayo, M Hudson, SR Shultz, NC Jones and TJ O’Brien. Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau. Brain v.139, p1919-38, 2016
  • G Dezsi, E Ozturk, M Salzberg, M Morris, TJ O'Brien, NC Jones. Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety. Neurobiology of Disease. v.93, p:129-36, 2016.
  • P Anderson, NC Jones, TJ O’Brien and D Pinault. The N-methyl D-aspartate glutamate receptor antagonist ketamine disrupts the functional state of the corticothalamic pathway. Cerebral Cortex.v.27, p:3172-3185, 2017
  • SJ Liu, Y Shen, S Shultz, A Nguyen, C Hovens, P Adlard, A Bush, J Chan, P Kwan, T O’Brien, NC Jones. Epileptogenesis is exacerbated by hyperphosphorylation of tau in mice. Epilepsia, v. 58(9), e136-141, 2017
  • J Lee, M Hudson, TJ O’Brien, J Nithianantharajah, NC Jones. Local NMDA receptor hypofunction evokes generalised effects on high frequency gamma oscillations and behaviour. Neuroscience, v. 358, 124-36, 2017.
  • G Dezsi, F Sieg, M Thomas, TJ O’Brien, M van der Hart, NC Jones. Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy. Neurochemical Research. v.42, p:2055–2064. 2017
  • NC Jones, M Hudson, J Foreman, G Rind, R Hill, EE Manning and M van den Buuse. Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice. European Journal of Neuroscience, accepted.