Jones group

Epilepsy & Behaviour lab

Key terms

Epilepsy, Stress, Behaviour, Cognition, Schizophrenia, Animal models, Anti-epileptogenic strategies, translational medical research

Back row (L - R) - A/Prof Nigel Jones (Lead), Ms Jennifer Tinston, Dr Idrish Ali, Ms Gabi Deszi, Ms Samantha Warren, Mr Runxuan Lin, Ms Flavia Gomes. Front row (L - R) - Ms Peravina Thergarajan, Dr Juliana e Silva, Dr Matt Hudson, Ms Debbie Chong, Ms Janine Liu, Ms Anna Harutyunyan, Ms Chitra Vinnakota.
Absent - Archita Sivakumar, Jeff (Hattapark) Dejakaisaya, Gadeer al-Hobaish, Fiona Qiu, Yifan Huang

Honours and Postgraduate research projects

Group Leader - A/Prof Nigel Jones

A/Prof Nigel Jones's research focuses on psychiatric disorders in epilepsy.

E: nigel.jones@monash.edu | P: +61 3 9903 0862

Find out more about A/Prof Nigel Jones

Research Goal

To explore relationships between epilepsy and its psychiatric comorbidities, and to develop disease-modifying therapies targeting underlying biological mechanisms. In addition, we aim to understand the cellular and biological basis of cognitive dysfunction in disorders such as schizophrenia.

Research Overview

Our research utilises discovery science approaches to explore animal behaviour in the context of health and disease. The primary goal of the lab is to understand the pathophysiological mechanisms which cause neurological and neuropsychiatric disorders, particularly epilepsy, cognitive disorders and mental health conditions. We employ of a range of advanced behavioural tests of cognition, anxiety, and depression, coupled with in vivo electrophysiology, molecular biology, in vivo imaging, opto/chemogenetic, immunocytochemical and transgenic methods to achieve this goal. We also study the role and influence of neuronal oscillations in cognitive behaviours in physiological circumstances, using sophisticated behavioural tasks and high-end electrophysiological recordings.

Projects

Current Competitive Project Funding:

  • NHMRC Project grant APP1157353 (2019-2022): NC Jones, A Pitkanen. Antidepressants in Epilepsy
  • NHMRC Project grant APP1156733 (2019 – 2021): NC Jones; Functional disconnections in schizophrenia
  • NHMRC Project grant APP1105666 (2016 – 2020): A McCluskey, PJ Robinson, NC Jones; A new approach for treating intractable epilepsy
  • NIH/NINDS Centre Without Walls NINDS RFA-NS-16-012 (2018-2022): NC Jones (Investigator) The Epilepsy Bioinformative study for antiepileptogenic therapy (EpiBioS4Rx)
  • Monash University Establishment grant (2018 – 2022): NC Jones

All recent publications can be seen at Orcid

Selected recent publications

All recent publications can be seen at Orcid

Click on tabs below for a list of publications in each area

  • P Thergarajan, JA Hamilton, TJ O’Brien, I Ali, NC Jones. Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity. Epilepsia, v.61(2), 203-215, 2020
  • S Carron, G Dezsi, E Ozturk, J Nithianantharajah, NC Jones. Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen‐based translational tools. Epilepsia, v. 60(8), pp. 1650-1660, 2019
  • C Li, J Silva, E Ozturk, G Dezsi, TJ. O’Brien, T Renoir, NC Jones. Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors, Epilepsia, v59(7), e114-119, 2018.
  • S-J Liu, Y Shen, S Shultz, A Nguyen, C Hovens, P Adlard, A Bush, J Chan, P Kwan, T O’Brien, NC Jones. Epileptogenesis is exacerbated by hyperphosphorylation of tau in mice. Epilepsia, v. 58(9), e136-141, 2017
  • G Dezsi, E Ozturk, M Salzberg, M Morris, T O'Brien, NC Jones. Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety. Neurobiology of Disease. v.93, p:129-36, 2016.
  • S-J Liu, P Zheng, DK Wright, G Dezsi, E Braine, T Nguyen, NM Corcoran, LA Johnston, CM Hovens, JN Mayo, M Hudson, SR Shultz, NC Jones, TJ O’Brien, Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau. Brain v.139, p1919-38, 2016
  • MR Hudson, E Sokolenko, TJ O’Brien, NC Jones. NMDA receptors on parvalbumin-positive interneurons and pyramidal neurons both contribute to MK-801 induced gamma oscillatory disturbances: Complex relationships with behaviour. Neurobiology of Disease, v.134, 104625, 2020.
  • E Sokolenko, MR Hudson, J Nithianantharajah, NC Jones. The mGluR2/3 agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice. Journal of Psychopharmacology, v.33(12), p1588-1599, 2019.
  • M Hudson, G Rind, TJ O’Brien, NC Jones. Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine. Translational Psychiatry, v.6, e784. 2016

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