Jupp Group

Key terms

Cognitive and behavioural neuroscience, Addiction, Impulsivity, Neuroimaging, Neuropharmacology

Research Goal

To investigate the neurobiological basis of individual vulnerability to drug addiction and associated behavioural traits.

Research Overview

Affecting over 39 million people worldwide, drug addiction represents one of the leading causes of preventable death and disease in the developed world. Curiously, despite the prevalence of drug use within society only a relatively small proportion of users go on to develop addiction. The biological mechanisms underlying this differential vulnerability however, remain largely unknown. Importantly these mechanisms may represent potential targets for the development of therapeutics to treat, or indeed, prevent this chronic disease.

To investigate this, our work aims to elucidate the molecular and neural substrates of various behavioural traits co-expressed in individuals at risk for addiction, such as impulsivity, and determine how these in turn contribute to the emergence of addictive behaviour. This work predominantly utilises neuroimaging approaches (MRI and PET) combined with the more conventional molecular and pharmacological techniques in rodent models.

Projects

Selected Recent Publications

For full list of publications, visit Pubmed.

Google scholar profile.

  1. Jupp B, Jones JA, Dalley JW (2019). Modelling differential vulnerability to addiction in rodents: neurobiological mechanisms. In Substance Use Disorders: Handbook of Experimental Pharmacology, Michael Nader and Yasmin Hurd, Springer.
  2. Jupp B, Murray JE, Jordan ER, Xia J, Fluharty M, Shrestha S, Robbins TW, Dalley JW (2016).  Social dominance in rats: effects on cocaine self-administration, novelty reactivity and dopamine receptor binding and content in the striatum. Psychopharmacology 233(4):579-89
  3. Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak S, Howett D, McKenzie C, Caprioli D, Besson M, Robbins TW, Everitt BJ, Dalley JW, Belin D (2016). From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive disorders. Molecular Psychiatry 21(4):491-9
  4. Caprioli D, Jupp B, Hong Y, Sawiak S, Ferrari V, Wharton L, Williamson D, McNabb C, Berry D, Aigbirhio F, Robbins T, Fryer T, Dalley JW, (2015). Dissociable rate dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum. Journal of Neuroscience 35(9):3747-55.
  5. Jupp B, Dalley, JW (2014). Behavioral endophenotypes of drug addiction: etiological insights from neuroimaging studies. Neuropharmacology. 76:487-97.
  6. Jupp B, Dalley, JW (2014). Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. British Journal of Pharmacology 171(20):4729-66.