Monif group

Neuroimmunology, Neuroinflammation and Neurological Diseases Laboratory

Key terms

Neurology, Neuroimmunology, Neuroinflammation, Multiple Sclerosis, Autoimmune Encephalits, Gliomas, Microglia, Purinergic Receptors

The group


2018 Monif group. L-R: Ms Katrina Kan, Mr William O'Brien, Dr Mastura Monif, Dr Robb Wesselingh, Ms Veronica Woo, Dr James Broadley

Research Goal

To understand how neuroinflammation can lead to neurological diseases.

Research Overview

Our research goals are to understand the neuroinflammatory and neuroimmunological processes in a number of neurological conditions. Our research is transitional in nature involving bed (hospital) to bench (laboratory) neuroscience approaches. The key disease states that we focus on are Multiple Sclerosis, Autoimmune Encephalitis, Human Gliomas, Stroke related neuroinflammation, and traumatic brain injury and neuroinflammatory cascades.

Projects

Current Project Funding

2017-19   Haynes Fellowship (Neurosciences Foundation; Royal Melbourne Hospital)
2018 Penny Cook Foundation

Selected Publications

See recent publications for Mastura Monif at Pubmed search [Monif M]

  • Monif M., Seneviratne U., (2017) Clinical factors associated with the yield of routine outpatient scalp electroencephalogram: A retrospective analysis from a tertiary hospital. Journal of Clinical Neuroscience. 45:110
  • Monif M., Reid CA, Powell K L, Drummond KL, O’Brien TJ, Williams DA (2016) Interleukin-1β is a key player mediating P2X7 receptor dependent microglial activation and proliferation. Journal Of Neuroinflammation 13: 173
  • Monif M, O’Brien TJ, Drummond KJ, Reid CA, Luibinas SV, Williams DA (2014) P2X7 Receptors are a potential novel target for anti-glioma therapies. Journal of Inflammation, 11:25
  • Williams DA, Monif M, Richardson, K (2012). Compartmentalizing Genetically-Encoded Calcium Sensors.  Calcium Signalling Protocols. Series: Methods in Molecular Biology. Volume 937, 3rd edition, ISBN:978-1-62703-086-1
  • Monif M., Williams DA (2011). Neuroinflammatory processes in the pathogenesis of Alzheimer’s disease. Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers, 2011, Chapter 2,  ISBN: 978-1-61942-462-3
  • Monif M, Reid CA, Powell KL, Smart ML, Williams DA (2009) The P2X7 receptor
    drives microglial activation and proliferation: a trophic role for P2X7R pore. J
    Neuroscience. 29:3781-3791.
  • M. Monif, Burnstock G, Williams DA (2010). Microglia: Proliferation and activation driven by the P2X7 receptor. International Journal of Biochemistry and Cell Biology (Cells in Focus review article).42:1753-6