Cardiovascular and Metabolic Health
We have particular skills in:
the pharmacology of G protein-coupled receptors and the role of allostery and biased signalling in receptor pharmacology
structure-based drug design and the use of fragment-based screening in drug discovery
identification of optimal pharmaceutical properties for drug molecules during hit-to-lead and lead optimisation through to candidate selection
oral and pulmonary drug delivery and the use of nanomedicines in optimised drug therapy
cellular and animal physiology of cardiovascular and metabolic disease models
pharmacoepidemiology and pharmacometrics
Cardiovascular research View
Cardiovascular research programs have a focus on delineating the underpinning mechanisms and developing new treatments for heart failure, diabetic cardiomyopathy and cardiopulmonary diseases.
Metabolic research View
Metabolic research programs focus on understanding how excess nutrient consumption and nonfunctioning metabolic organs contribute to obesity, diabetes and metabolic associated cancers, thus enabling the development of improved treatments for metabolic associated diseases.