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A study on the new powerful semi-synthetic methodology, EPSL, that facilitates the rapid and efficient ligation of expressed protein selenoesters with modified synthetic selenopeptides
A study on using the synthetic platform to generate and characterize peptide and protein libraries for identifying lead candidates in medicinal chemistry.
Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
