Monash Fragment Platform View
The Monash Fragment Platform (MFP) designs and runs fragment-based drug discovery (FBDD) campaigns for new therapeutic targets. FBDD screening uses a high-quality, in-house fragment library designed to maximise chemical space coverage and enable rapid hit optimisation. Screening cascades are tailored and use a variety of physical techniques such as NMR and surface plasmon resonance (SPR). Bespoke medicinal chemistry support subsequently facilitates Rapid Elaboration of Fragments into Leads (REFiL), to power translation.
Monash Proteomics and Metabolomics Facility View
The Monash Proteomics and Metabolomics (MPMF) Parkville node provides cutting edge metabolomics, lipidomics and proteomics capabilities for MIPS researchers and the wider research community. Our analytical methods are suitable for samples arising from cell culture, animal studies or clinical trials, and our workflows are ideally suited to untargeted comparative analyses.
Australian Translational Medicinal Chemistry Facility View
The Australian Translational Medicinal Chemistry Facility (ATMCF) is a purpose-designed, outward-facing, collaborative facility that supports early stage medicinal chemistry-led drug discovery. ATMCF provides medicinal chemistry insight and expertise and a translational bridge between early-stage biology and translational lead optimisation and pre-clinical development.
Centre for Drug Candidate Optimisation View
The Centre for Drug Candidate Optimisation (CDCO) provides expertise and infrastructure in Absorption-Distribution-Metabolism-Excretion (ADME) and pharmacokinetic (PK) profiling during lead optimisation for multidisciplinary drug discovery teams to improve compound design, selection and progression through to drug candidate selection.
HMSTrust Analytical Laboratory View
The HMSTrust Laboratory is an open-access analytical facility that uses sophisticated physical and chemical characterisation techniques to overcome challenges faced in modern drug development. Academic and industry researchers can access a comprehensive suite of advanced chemical characterisation instruments.
Medicines Manufacturing and Innovation Centre View
Medicines Manufacturing Innovation Centre (MMIC) is an initiative established with the Victorian State Government to bring academic and industrial scientists together to optimise manufacturing processes, enhance current and new product development and build a highly skilled, industry ready, workforce. MMIC provides specialist analytical and formulation development services via a team of experienced industrial scientists.
Structural biology, analytical pharmacology, imaging and in vivo models View
MIPS has significant capability in cryo-EM, NMR and crystallography and the use of this information in structure based drug design. We house an extensive range of ultra-precision microscopes include widefield, high throughput, holographic, hyperspectral, electron, super-resolution, confocal, multiphoton, lifetime imaging and label free confocal. We also provide analytical and sorting flow cytometry (FACS).