What are organoids

Organoids are an innovative 3Dcell culture system that can be used for personalised medicine or discovery research.

Organoids are simplified miniature versions of an organ grown in the laboratory.

Human small intestinal organoid

Human small intestinal organoid.

They are made up of clusters of cells, including a subset of stem cells which self-renew and then mature into various organ-specific cell types.  These three-dimensional cell clusters mimic much of the architecture and physiological function of the original tissue.

Organoids can be generated from normal or diseased tissue, including cancers.

Once established, they can continually be grown and expanded in culture, as well as frozen and stored for future use.

Importantly, organoids can be grown from patient samples offering new opportunities to determine personalised therapies for individuals, understand cancer biology, and improve drug development.