Organoid Program news

Recent  Publications

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential, C. M. Nefzger, T. Jardé, A. Srivastava, J. Schroeder, F. J. Rossello, K. Horvay, M. Prasko, J. M. Paynter, J. Chen, C. F. Weng, . B. Y. Sun, X. Liu, E. Chan, N. Deshpande, X. Chen, Y. J. Li, J. Pflueger, R. M. Engel, A. S. Knaupp, K. Tsyganov, S. K. Nilsson, R. Lister, O. J. L. Rackham, H. E. Abud, J. M. Polo (2022) , NPJ Regenerative Medicine

Modeling colorectal cancer: A bio-resource of 50 patient-derived organoid lines, R. M. Engel, T. Jardé, K. Oliva, G Kerr, W. H. Chan, S. Hlavca, D. Nickless, S. K. Archer, R. Yap, P. Ranchod, S. Bell, A. Niap, C. Koulis, A. Chong, S. Wilkins, T. C. Dale, A. J. Hollins ,P. J. McMurrick, H. E. Abud (2022),  Journal of Gastroenterology and Hepatology.

Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models, N. J. Chew, T. C. C. L. K. Sian, E. V. Nguyen, S.Y. Shin, J. Yang, M. N. Hui, N. Deng, C. A. McLean, A. L. Welm, E. Lim, P. Gregory, T. Nottle, T. Lang, M. Vereker, G. Richardson, G. Kerr, D. Micati, T. Jardé, H. E. Abud, R. S. Lee, A. Swarbrick & R. J. Daly (2021), Breast Cancer Research.

A thermo-responsive collagen-nanocellulose hydrogel for the growth of intestinal organoids, R. Curvello, D. Alves, H. E. Abud, G. Garnier (2021) Materials Science & Engineering C.

Engineered Plant-based Nanocellulose Hydrogel for Small Intestine Organoid Growth, R. Curvello, G. Kerr, D.J. Micati, W.H. Chan, V. S. Rashuwanshi, J Rosenbluh, H. E. Abud, G. Garnier (2020), Advanced Materials.

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression, H. Y. K.Yip, A.Chee,C.S. Ang,S.Y. Shin, L. M. Ooms,Z. Mohammadi, W. A. Phillips, R. J. Daly, T.J. Cole, R. T. Bronson, L. K. Nguyen, T. Tiganis, R. M.Hobbs, C. A. McLean, C. A. Mitchell, A. Papa (2020), Molecular Cell.

Mesenchymal niche-derived Neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium, T. Jardé, W. H. Chan, F. J. Rossello, T. Kahlon, M. Theocharous, T. K. Arackal, T. Flores, M. Giraud, E. Richards, E. Chan, G. Kerr, R. M. Engel, M. Prasko, J. F. Donoghue, S. Abe, T. J. Phesse, C. M. Nefzger, P. J. McMurrick, D. Powell, R. J. Daly, J. M. Polo, H. E. Abud (2020), Cell Stem Cell.

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease, S. Mileto, T. Jarde, K. O Childress, J. L. Jensen, A. P. Rogers, G. Kerr, M. L. Hutton, M. J. Sheedlo, S. C. Bloch, J. A. Shupe, K. Horvay, T. Flores, R. Engel, S. Wilkins, P. J. McMurrick, D. B. Lacy, H. E. Abud, D. Lyras, (2020), PNAS.

Patient-Derived Colorectal Cancer Organoids Upregulate Revival Stem Cell Marker Genes following Chemotherapeutic Treatment, R. M. Engel, W. H. Chan, D. Nickless, S. Hlavca, E. Richards, G. Kerr, K. Oliva, P. J. McMurrick, T. Jardé, H. E. Abud, (2020), Journal of Clinical Medicine

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