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The active-state A1 adenosine receptor structure with Gi2 protein reveals insights into G-protein selectivity and receptor activation mechanisms
Antagonist-bound A1 receptor structure (3.2 Å resolution) shows major differences in extracellular loops compared to A2A, and wide A1 receptor cavity offers insights into allosteric drug actions
The concept of kinetic context represents an important new consideration that should be routinely incorporated into contemporary chemical biology and drug discovery studies of GPCR bias and allostery
