Atherosclerosis and Cardiovascular Inflammation Group
About the Atherosclerosis and Cardiovascular Inflammation Group
Heart disease is the number one killer in our community. The underlying basis of it is the thickening of arteries by the pathological process of atherosclerosis; an occlusive disease of arteries that causes heart attacks and strokes. While a high fat diet plays an initiating role, inflammatory and immunological mechanisms play essential roles in the progression of lesions to advanced vulnerable plaques, the rupture of which triggers thrombotic occlusion of arteries supplying the heart and brain.
In collaboration with Professor Alex Bobik of the Baker Heart & Diabetes Institute our efforts are directed towards a precise understanding the role of the innate and adaptive immune system in the initiation and progression of atherosclerosis. We're using this new-found knowledge in clinical settings to treat and significantly reduce mortality from heart attacks and strokes.