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Clinical Trials, Imaging and Informatics Division

The Clinical Trials, Imaging and Informatics (CTI) division of the Stroke and Ageing Research Group has several facets. An important focus is the conduct of clinical trials (investigator initiated and industry sponsored) trials in acute and secondary stroke prevention. Members of this division are significant contributors to trials such as the Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND-IV) trial and Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) trial. A new focus is to explore the utility of knowledge discovery and data mining in stroke and aging research. The CTI group welcomes collaboration on projects other than stroke and aging.

Prof Thanh Phan and Prof Henry Ma are acute stroke specialists and neurologists with clinical and research expertise in acute stroke and TIA, endovascular therapy, advanced brain imaging, and the use of novel bioinformatics, geospatial analysis, spatial epidemiology, operational research, cost analysis, and big data approaches in stroke care. The group has received the NHMRC Clinical Trial and Cohort Studies grant to conduct clinical trial of thrombectomy for management of stroke resulting from medium vessel occlusion.

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Meet the team View

Projects

1. Impact of dysphagia screen on medication compliance
2. Antihypertensive medication usage and discharge delay in Stroke Unit
3. Hospital handover
4. Detecting error propagation in medical record
1. Monash TIA Triaging and Treatment (M3T) system, an alternative model of TIA care to avoid hospital admission
2. Monash Minor Stroke Pathway
1. Hospital re-design incorporating spatial information
  1. Mapping hospital catchment in Melbourne and Sydney
  2. App to direct transport of patients to appropriate hospital
  3. Defining operating characteristics of Mobile Stroke Unit/CT ambulance
2. Forecasting of disease morbidity and mortality
  1. Minimum dataset requirement
3. Telemedicine
  1. Re-evaluating cost effectiveness of telemedicine
  2. Efficiency and resilience of telemedicine network
  3. Optimal design of telemedicine network
4. Effectiveness of social media campaign to educate the public on recognition of stroke signs.
5. Optimal design of advisory board and expert group to advise policy makers-using graph theoretical analysis and cooperative game theory
1. Computer modelling of collateral circulation
  1. Blood flow in acute stroke in middle cerebral artery and anterior cerebral artery
  2. modelling effect of endovascular procedures on blood flow
2. Mapping of neurological deficit in acute stroke
  1. Bayesian analysis of likelihood of infarct given stroke intervention
3. Penumbral imaging
  1. Topography
1. Post-stroke mood disorders
2. Mapping of vascular anatomy and infarct topography
3. DTI:-Impact of corticofugal fibers involvement and motor deficit
4. Stratifying bleeding risk in atrial fibrillation
1. Prediction of outcome in intracerebral hemorrhage
1. TMS in stroke recovery
2. driving after stroke
3. Applying prediction models to stroke rehabilitation
1. Atherosclerosis
  1. Carotid artery geometry and risk of atherosclerosis
  2. PET imaging of vulnerable carotid plaque
  3. Glagov phenomenon at the carotid bifurcation
  4. Principle of minimum work at the carotid bifurcation and beyond
  5. Mining literature on atherosclerosis
2. Small vessel disease
  1. defining lacunar infarct
  2. mapping lacunes in CADASIL (Australian, French, German, Scottish collaboration)
3. Stroke in young patients
  1. Fabry disease
  2. Patent foramen ovale-in innocent bystander?
  3. cerebral vasculitis
1. EXTEND-IV- A/Prof Henry Ma is the principal coordinator of this multicentre trial
2. TASTE trial-NHMRC funded project grant (collaboration with international team)
3. STAND-FIRM trial – Improving secondary stroke prevention in the community (led by Prof Amanda Thrift)
4. I-ACT trial with stem cell in acute ischaemic stroke (collaboration with Dr Rebecca Lim, Prof Euan Wallace, Prof Chris Sobey). Phase 1-Trial registration ACTRN12618000076279p
5. Biomarkers in acute stroke (collaboration between A/Prof Henry Ma and Dr Connie Wong)
1. Seizure treatment (collaboration with A/Prof Udaya Seneviratne)
  1. Decision making under uncertainty
  2. Theme discovery in medical records of patients with pseudoseizure
  3. Health care burden of pseudoseizure
2. Gait disorders
  1. Neuroimaging of gait disorders
  2. mining medical records of fall risk
3. Coma and Disorder of Consciousness
  1. Prediction of outcome following coma
  2. Meta-analysis of studies on predictors of coma
4. Multiple sclerosis-profiling phenotypes
5. Motor neuron disease (profiling phenotypes, outcome, service planning, health care survey)
6. Movement disorder-mitochondrial role in Parkinson disease
- Disease mapping
  - Hip fracture
  - Cancer
  - Birth
- Education of junior staff on seizure recognition
1. Natural language processing
  1. Mining literature on atherosclerosis
  2. Theme discovery in publications on lacunar stroke
  3. Theme discovery in medical records of patients with TIA
  4. Sentiment analysis of health care survey e.g. neurodegenerative disease
2. Geospatial analysis
  1. Modelling transport system in health care
  2. Mapping hospital catchment care in Melbourne and Sydney
  3. Decision tool in transportation of patients with acute stroke
  4. Effect of staff residence on response to acute medical emergencies
  5. Disease mapping
    1. TIA and Stroke
3. Social media and web scraping
  1. Assessing success of social media campaigns for public education on stroke recognition
  2. Analysis of tweets following negative trials in major journals
4. Graph theoretical analysis
  1. Graph theoretical analysis of relationship between infarct location and disability
  2. Efficiency and resilience of telemedicine network
  3. Dynamic network-interactions among acute stroke team
  4. Social network and post stroke recovery
5. Recommender system
  1. Role in physician decision making
  2. Role in junior doctor decision making
  3. Profiling multiple sclerosis phenotypes
  4. Profiling motor neurone disease phenotypes
6. Discrete event simulation
  1. Optimisation of hospital network
  2. Optimisation of acute stroke team

Clinical Sciences at Monash Health

Medicine, Nursing and Health Sciences

Clinical Trials, Imaging and Informatics Division

Meet the team View

Researchers

Projects