Sarcopenia, Obesity and Lifestyle Laboratory
The Sarcopenia, Obesity and Lifestyle laboratory is led by Dr David Scott, a NHMRC Career Development Fellow within the Bone and Muscle Research Group at the School of Clinical Sciences at Monash Health. Our research explores the contributions of age-related changes in body composition to functional decline and loss of independence in older adults. We collaborate on a several national and international cohort studies to investigate associations of sarcopenia (the age-related decline in skeletal muscle mass and function) and obesity with development of poor bone health, disability and falls and fractures. We also utilise these datasets to identify lifestyle behaviours that prevent muscle and bone quality declines during ageing. We are currently conducting trials exploring how to best deliver lifestyle modification to community-dwelling older adults at high risk for functional decline. These trials include physical activity and nutrition interventions such as osteogenic exercise, resistance training, weight loss and vitamin D supplementation.
- The Osteo-Dev Study: Developing a wearable device to measure exercise impacts related to bone health
- The D-Ex Study: A randomised controlled trial of vitamin D and community-based exercise for improving physical performance in obese older adults
- The ESPRESSO-P Study: A pilot study of home-delivered exercise for improving balance and muscle strength in obese older adults with sarcopenia
- The OSMOSIS-P Study: A pilot study of community-based high-intensity exercise for reducing bone and muscle declines during weight loss
- Tasmanian Older Adult Cohort Study (TASOAC) – Prof. Graeme Jones and Dr. Dawn Aitken (Menzies Institute for Medical Research, Tasmania)
- Perth Longitudinal Study of Ageing Women (LSAW) – Dr. Joshua Lewis and Dr. Marc Sim (Edith Cowan University, Western Australia)
- Concord Health and Ageing in Men Project (CHAMP) – Dr. Vasant Hirani and Prof. Robert Cumming (University of Sydney, New South Wales)
- VITAL-D Study – Prof. Kerrie Sanders (University of Melbourne, Victoria)
- The Healthy Ageing Initiative – Prof. Anna Nordstrom and Prof. Peter Nordstrom (Umea University, Sweden)
- Sim M, Prince RL, Scott D, Daly RM, Duque G, Inderjeeth C, Zhu K, Woodman RJ, Hodgson JM, Lewis JR (2018). Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women. Osteoporosis International (In press).
- Sim M, Prince RL, Scott D, Daly RM, Duque G, Inderjeeth C, Zhu K, Woodman RJ, Hodgson JM, Lewis JR (2018). Sarcopenia definitions and their associations with mortality in older Australian women. Journal of the American Medical Directors Association (In press).
- Zanker J, Scott D, Reijnierse EM, Brennan-Olsen SL, Daly RM, Girgis CM, Grossmann M, Hayes A, Henwood T, Hirani V, Inderjeeth CA, Iuliano S, Keogh J, Lewis J, Maier AB, Pasco JA, Phu S, Sanders KM, Sim M, Visvanathan R, Waters DL, Yu SCY, Duque G on behalf of the Australian and New Zealand Society for Sarcopenia and Frailty Research Task Force on Diagnostic Criteria for Sarcopenia (2018). Establishing an Operational Definition of Sarcopenia in Australia and New Zealand: Delphi Method Based Consensus Statement. Journal of Nutrition, Health and Aging (In press).
- Scott D, Cumming RG, Blyth F, Naganathan V, Le Couteur DG, Waite LM, Handelsman DJ, Seibel MJ, Hirani V (2018). Does combined osteopenia/osteoporosis and sarcopenia confer greater risk of fracture than either condition alone in older men? The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences (In press).
- McMillan LB, Aitken D, Ebeling P, Jones G, Scott D (2018). The relationship between objectively-assessed physical activity and bone health in older adults differs by sex and is mediated by lean mass. Osteoporosis International (In press).
- Scott D, Shore-Lorenti C, McMillan L, Mesinovic J, Clark RA, Hayes A, Sanders KM, Duque G, Ebeling PR (2018). Associations of components of sarcopenic obesity with bone health and balance in older adults. Archives of Gerontology and Geriatrics 75:125-31.
- Scott D, Shore-Lorenti C, McMillan L, Mesinovic J, Clark RA, Hayes A, Sanders KM, Duque G, Ebeling PR (2018). Calf muscle density is independently associated with physical function in overweight and obese older adults. Journal of Musculoskeletal and Neuronal Interactions (In press)
- McMillan L, Zengin A, Ebeling PR, Scott D (2017). Prescribing physical activity for the prevention and treatment of osteoporosis in older adults. Healthcare 5(4):85.
- Sanders K, Lim K, Stuart A, Macleod A, Scott D, Nicholson G, Busija, L (2017). Diversity in fall characteristics hampers effective prevention: The precipitants, the environment, the fall and the injury. Osteoporosis International 28(10):3005-15.
- Rodriguez A, Scott D, Khan B, Khan N, Hodge A, English DR, Giles GG, Ebeling PR (2017). Associations between hip bone mineral density, aortic calcification and cardiac workload in community-dwelling older Australians. Osteoporosis International 28:2239-45.
- Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V (2017). Sarcopenic obesity and its temporal associations with changes in bone mineral density, incident falls and fractures in older men: The Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research 32(3):575-83.
- Scott D, De Courten BD, Ebeling PR (2016). Sarcopenia: A potential cause and consequence of type 2 diabetes mellitus in Australia’s ageing population? Medical Journal of Australia 205(7):329-33. IF = 3.369
- Scott D, Chandrasekara SD, Laslett LL, Cicuttini F, Ebeling PR, Jones G (2016). Associations of sarcopenic obesity and dynapenic obesity with bone mineral density and incident fractures over five to 10 years in community-dwelling older adults. Calcified Tissue International 99(1):30-42.
- NHMRC R.D. Wright Biomedical Career Development Fellowship: Reducing Risk Factors for Falls and Fracture in Obese Older Australians. PI: David Scott
- Rebecca L. Cooper Foundation Project Grant: Exercise for Musculoskeletal and Metabolic Health During Weight Loss in Sarcopenic Obese Older Adults. PI: David Scott
- American Society for Bone and Mineral Research Rising Star Award: The Exercise for the Prevention of Falls in Older Adults with Sarcopenic Obesity Pilot Study (ESPRESSO-P). PI: David Scott
- MIME-SPARK Scheme: Wearable sensors to optimise exercise for bone health. PIs: David Scott, Peter Ebeling