André Samson
Dr André Samson is the Head of the Gut Inflammation group at the Centre for Inflammatory Diseases at Monash University. His group investigates the cellular and molecular mechanisms that underlie diseases such as Crohn’s disease and ulcerative colitis. Prior to joining Monash University, Dr Samson was a Team Leader in the Inflammation Division at the Walter and Elisa Hall Institute for Medical Research, where his team studied the models, mechanisms and clinical ramifications of an inflammatory form of cell death known as necroptosis.
Research interests
- Gut inflammation
- Inflammatory Bowel Disease (IBD)
- Crohn’s disease (CD)
- Ulcerative colitis (UC)
- Cell death
- Necroptosis
Publications
Below are a selection of some of published studies reflecting our high impact work. For a full list of our publications, please visit PubMed link and Google Scholar.
- A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease Jiyi Pang#, Aysha H. Al-Ani#, ...Hawkins*, Britt Christensen*, Andre L. Samson*, James E. Vince*, James M. Murphy* et al. Journal: Science. 2026. #co-first, *co-senior
- An immunohistochemical atlas of necroptotic pathway expression Shene Chiou, Aysha H Al-Ani, ...James M Murphy*, André L Samson*. EMBO Molecular Medicine. 2024;16(7):1717-1749 (preprinted on bioRxiv Nov 2023) *co-senior
- The kinase domain of RIPK3 tunes its scaffolding functions Shene Chiou, Christopher R Horne, ...Edwin D Hawkins*, ANDRE L SAMSON*, James M Murphy* Cell Death & Differentiation. 2026 Feb 3. Online ahead of print. *co-senior
- Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria Stefanie M Bader, Simon P Preston, Katie Saliba, ...Marc Pellegrini*, Andre L Samson* Cell Death & Differentiation. 2023 Jan;30(1):27-36 *co-senior
- A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells Andre Samson, Cheree Fitzgibbon, Komal M et al. Cell Death & Differentiation. 2021 Jul;28(7):2126-2144
- MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis Andre L Samson, Ying Zhang, et al. Nature Communications. 2020;11(1):3151