Joohyung Lee
Joohyung Lee, PhD
Dr Joohyung Lee is a Head of the Sex Chromosome Neurobiology in the Department of Psychiatry at Monash University, Australia. His laboratory seeks to better understand how sex chromosome genes influence brain function, behaviour and immunity and ii) how sex chromosome genes may influence sex differences underlying neurodevelopmental and neurodegenerative disorders and iii) identify sex-specific risk or protective factors to develop more effective therapies for each sex.
His group previously showed that the Y-chromosome gene, SRY, exerts male-specific actions on dopamine neurons and that aberrant SRY upregulation drives male-specific neurodegeneration in experimental models of Parkinson’s disease. His group now seeks to better understand the cellular and molecular pathways regulated by SRY in the male brain and the immune system. The ultimate goal is to develop novel male-specific therapies to target SRY for diverse conditions such as Parkinson’s disease, autism, hypertension and viral infections – which disproportionately affects males compared to females.
To find out more see Dr Joohyung Lee's Monash profile.