Dr Ooi is an Al and Val Rosenstrauss Fellow in the School of Clinical Sciences at Monash Health. His lab focusses on generating autoantigen-specific regulatory T cells to treat autoimmune diseases.
During his PhD (2009) and post-doctoral training, Dr. Ooi showed that inflammatory T helper cells specific for self proteins (known as autoantigens) underlie the pathogenesis of autoimmune disease. Now, Dr. Ooi and his team are devising regulatory T cell based therapies that specifically switch off the autoantigen-specific inflammatory response.
His work has been published in the top journals including in PNAS, J Clin Invest and Nature; and he has received funding by the NHMRC, Rebecca Cooper Medical Research Foundation and the Lupus Research Alliance to develop these new and innovative therapies.
- Identification of autoimmune T cell epitopes and T cell receptors (TCRs)
- Generation of antigen specific regulatory T cells
- Cell based therapies to treat autoimmune disease
Find out more about Dr Joshua Ooi.