This study aims to identify genetic risk factors that predispose people to these rare atypical femur fractures in order to find ways to prevent them.
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This sub-study aims to identify the incidence of atypical femur fractures, by reviewing medical records and radiological scans for all patients at Monash Health with femur fractures.
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Haemophilia is a genetic condition where there is a deficiency in a blood clotting factor, and mostly affects men. The severity of haemophilia is determined by the extent of clotting factor deficiency, ranging from mild, moderate to severe.
Treatment for haemophilia has improved immensely over the past 30 years and has increased the life expectancy in haemophilia patients. Fracture rates are higher in patients with haemophilia, with disease severity affecting fracture risk. We don’t know why haemophilia patients are at a higher risk of fractures or if bone loss begins earlier than in the general population.
This research study will be the first to focus on bone and muscle in patients with haemophilia A to understand why fracture rates are higher.
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Aboriginal and Torres Strait Islander Australians have a substantially greater fracture and falls risk than non-Indigenous Australians. This research study aims to understand why falls and fracture risk is higher, in order to improve screening and diagnosis of osteoporosis.
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After menopause, women do not produce sufficient estrogen or testosterone necessary for good bone health. They experience progressive bone loss, increasing their risk of osteoporosis (weakened bone strength) and fractures at a young age. This research is to determine whether the use of an approved low-dose of testosterone therapy restores testosterone levels to those of premenopausal women, prevents bone loss and improves sexual function in women with menopause.
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This trial aims to assess how safe and well tolerated a single dose of SAR439459 is in participants with Type I or Type IV Osteogenesis Imperfecta to increase bone strength and bone mineral density. Recruitment has closed but if you’re interested in future trials for this condition please contact us at med-bmrg@monash.edu
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This study aims to assess risk factors for broken bones sustained at low trauma. Broken bones may occur in people with normal bone density when there is ineffective transfer by bones of the forces associated with usual daily activities or low trauma.
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The research project is aiming to collect information on the presentation and long-term outcomes of patients with HPP, as well as information on the complications of both the condition and its management.
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This research project aims to learn more about an investigational medication called ALXN1850 (a trial medication similar to asfotase alfa): (i) to determine if ALXN1850 can be effective in the treatment of Hypophosphatasia; (ii) to better understand Hypophosphatasia as well as its associated health problems.
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This trial aims to review the medicines taken by patients of the Osteoporosis Refracture Prevention Clinic, in order to reduce falls and fractures. Some patients will have their medicines reviewed by a home visiting pharmacist. Recruitment for this trial is closing soon.
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The aim of this project is to collect bone and body composition scans using a high-resolution peripheral quantitative computed tomography (HRpQCT) scanner.
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What we do
Total time to complete this will be under an hour.
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Contact the Bone and Muscle Research Group via email expressing your interest (med-bmrg@monash.edu)