Newborn - Cell Therapies
- Associate Professor Atul Malhotra (Co-Director)
- Dr Courtney McDonald (Co-Director)
- Professor Michael Fahey
- Professor Rod Hunt
- Professor Graham Jenkin
- Associate Professor Rebecca Lim
- Professor Suzanne Miller
- Dr Tamara Yawno
Translating Promise into Benefits
Monash Newborn is a world leader in the translation of stem cell therapies for newborn diseases from the bench to the bedside. Monash Newborn clinicians along with colleagues from The Ritchie Centre, Hudson Institute of Medical Research conducted the first-in-human trial of placental stem cells for preterm lung disease (bronchopulmonary dysplasia). They are currently involved in multicentre trials of a variety of stem cell therapies for newborn lung and brain conditions.
To facilitate translation of cell therapy solutions for neonatal conditions.
To improve and facilitate pre-clinical and clinical research translation of neonatal cell therapy possibilities by bringing together scientists, clinicians, commercial partners, trial coordinators, clinical and research staff interested in cell therapies.
Find out more about us from the sections below:
Cord blood derived therapies
- CORD-Safe* (Safety and feasibility study in extremely preterm infants)
- STELLAR* (Feasibility and safety study of multiple infusions in infants with antenatally diagnosed fetal stroke)
- Preterm brain injury#
Expanded CD34+ cells
- Pre-clinical studies* (in vitro and in vivo studies)
Amnion derived cells
- RENEWAL* (Dose escalation study in preterm infants at high risk of bronchopulmonary dysplasia)
Exosomes/ Extracellular vesicles
Amnion derived EVs
- Pre-clinical studies* (in vitro and in vivo studies)
iPSC- derived MSCs
- NEO-Stem#(Safety study in infants with perinatal arterial stroke)
- Pre-clinical studies#
Neural stem cells
- Pre-clinical studies* (in vitro and in vivo studies)
Biennial workshop/ symposium – Showcasing latest preclinical and clinical research in neonatal cell therapies. Will include at least one international invited speaker.
Half-yearly update – Half-day workshop where students, researchers present the pre-clinical and clinical research progress for the last 6 months of the group. This will also include workshops and sessions on contract development, manufacturing, regulatory, intellectual property, patent strategy and other matters.
Half yearly executive meeting – This meeting would follow the half-yearly update and we would get the executive group together to assess the progress of the group, brain storm what needs to be done to progress certain areas, or raise concerns in areas that may benefit from redirection.
- Kit Connelly
- Ricki Marzan
- Tayla Penny
- Ishmael (Mikee) Inocencio
- Yen Pham
- Gordon McPhee
- Nancy Messino
- Mirja Krause
- Dandan Zhu
- Graeme Polglase
- David Wright
- Michael Ditchfield
- Mara Quach
- Siow Chan
- Yuan Chen
- Lindsay Zhou
- Abdul Razak
- Madeleine Smith
- Arya Jithoo
- Naveen Kumar
- Alex Bell
- John Rasko
- Bernard Thebaud
- Manon Benders
- Amir Khan
- Charles Cox
- Elizabeth Baker
- Peter Davis
- Madison Paton
- Iona Novak
- Nadia Badawi
- Ngaire Elwood
- Himanshu Popat
- Megan Finch-Edmondson
- Belinda Campbell
- Tatum Mitchell
- Brooke Hanson
- Cell Care Australia
- Generate Life Sciences
Selected media highlights
- Monash news - Giving Preterm Babies the Best Start
- The Australian - Stem cell ‘elixir’ hope for tiniest babies (news story accessible to subscribers)
- Monash news - Using stem cells to prevent brain damage in very preterm babies
- Monash news - Translating Promise into Benefits
- Monash news - Lions Foundation provides support to neonatal cell therapy research
- Monash news - Research on preterm brain injury treatment recognised
- Monash news - NHMRC Grant Success
- Mirage news - Long-term outcomes of world-first study involving stem cells for premature babies with chronic lung
- Mirage news - Protecting growth-restricted babies from brain injury with stem cell therapy
- Monash news - Monash Newborn Research success at Cerebral Palsy Alliance Research Grants
- Monash news: DHHS funding to help develop treatment for chronic lung disease in premature babies
- Monash news - World-first clinical trial using umbilical cord blood cells to treat COVID-19
- Channel 9 news - Major breakthrough with new therapy for premature babies
- Monash Lens - Stem cell treatment hope for babies with chronic lung disease
- Monash news - ‘Needle in a haystack’ of stem cells found – hope for cerebral palsy
2023 Monash Children's Hospital Gala - Friday 10 Feb 2023 7:00 pm - 11:59 pm
- Venue: Palladium at Crown, Level 1 Crown Towers, Crown Melbourne, 8 Whiteman St, Southbank VIC 3006, Australia
On one very special night every year, Monash Children’s Hospital (MCH) hosts a spectacular evening of entertainment and fundraising in support of our very special hospital. Funds raised at this year's event will help support vulnerable babies in NICU. This will allow a greater chance of our very premature babies to not only survive, but thrive!
Guests were treated to excellent food and entertainment and responded with outstanding generosity and enthusiasm. The over $1.2 million raised will make a positive difference in the lives of premature babies and their families.
2022 Neonatal Cell Therapies Symposium - 26 November 2022 8:00 am – 5:00 pm
- Venue: Novotel Melbourne on Collins, 270 Collins Street, Melbourne
- Open to: Scientists clinicians students
This First Ever Neonatal Cell Therapies Symposium showcased the best of preclinical and clinical advances with talks by leaders in the field. These include Prof Bernard Thebaud (University of Ottawa), Prof Alistair Gunn (University of Auckland) and a number of other national experts. There were opportunities for emerging leaders and students working in this space to submit abstracts, and present their research in the midst of experts.
- Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury: A Systematic Review & Meta-Analysis of Preclinical Studies.
Nguyen T, Purcell E, Smith MJ, Penny TR, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Int J Mol Sci. 2023 Feb 22;24(5):4351. doi: 10.3390/ijms24054351. PMID: 36901781 Free PMC article. Review.
- Factors Influencing the Efficacy of Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury.
Purcell E, Nguyen T, Smith M, Penny T, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Stem Cells Transl Med. 2023 Mar 17;12(3):125-139. doi: 10.1093/stcltm/szad006. PMID: 36847059 Free PMC article.
- Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs.
Bell A, Watt AP, Dudink I, Pham Y, Sutherland AE, Allison BJ, McDonald CA, Castillo-Melendez M, Jenkin G, Malhotra A, Miller SL, Yawno T.Stem Cell Res Ther. 2023 Feb 14;14(1):29. doi: 10.1186/s13287-023-03249-z. PMID: 36788590 Free PMC article.
- Feasibility of cord blood collection for autologous cell therapy applications in extremely preterm infants.
Zhou L, McDonald CA, Yawno T, Penny T, Miller SL, Jenkin G, Malhotra A. Cytotherapy. 2023 Feb 3:S1465-3249(23)00007-5. doi: 10.1016/j.jcyt.2023.01.001. Online ahead of print. PMID: 36740465
- Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community.
Smith MJ, Finch-Edmondson M, Miller SL, Webb A, Fahey MC, Jenkin G, Paton MCB, McDonald CA. Stem Cell Res Ther. 2023 Feb 3;14(1):18. doi: 10.1186/s13287-023-03246-2. PMID: 36737828 Free PMC article.
- Umbilical Cord Blood and Cord Tissue-Derived Cell Therapies for Neonatal Morbidities: Current Status and Future Challenges.
Zhou L, McDonald C, Yawno T, Jenkin G, Miller S, Malhotra A. Stem Cells Transl Med. 2022 Mar 17;11(2):135-145. doi: 10.1093/stcltm/szab024. PMID: 35259278 Free PMC article.
- Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function.
Watt AP, Kirkland M, Nekkanti L, Pham Y, McDonald C, Malhotra A, Moeneclaey G, Miller SL, Jenkin G. Cell Tissue Res. 2022 Apr;388(1):117-132. doi: 10.1007/s00441-022-03592-2. Epub 2022 Feb 2. PMID: 35106623 Free PMC article.
- Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies.
Smith MJ, Paton MCB, Fahey MC, Jenkin G, Miller SL, Finch-Edmondson M, McDonald CA. Stem Cells Transl Med. 2021 Dec;10(12):1621-1636. doi: 10.1002/sctm.21-0243. Epub 2021 Sep 20. PMID: 34542242 Free PMC article.
- Umbilical cord blood therapy modulates neonatal hypoxic ischemic brain injury in both females and males.
Penny TR, Pham Y, Sutherland AE, Lee J, Jenkin G, Fahey MC, Miller SL, McDonald CA. Sci Rep. 2021 Aug 4;11(1):15788. doi: 10.1038/s41598-021-95035-1. PMID: 34349144 Free PMC article.
- Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep.
Davidson JO, van den Heuij LG, Fraser M, Wassink G, Miller SL, Lim R, Wallace EM, Jenkin G, Gunn AJ, Bennet L. Stem Cells Transl Med. 2021 Mar;10(3):427-440. doi: 10.1002/sctm.20-0314. Epub 2020 Oct 26. PMID: 33103374 Free PMC article.
- Multiple doses of umbilical cord blood cells improve long-term brain injury in the neonatal rat.
Penny TR, Pham Y, Sutherland AE, Mihelakis JG, Lee J, Jenkin G, Fahey MC, Miller SL, McDonald CA. Brain Res. 2020 Nov 1;1746:147001. doi: 10.1016/j.brainres.2020.147001. Epub 2020 Jul 2. PMID: 32585139
- Autologous transplantation of umbilical cord blood-derived cells in extreme preterm infants: protocol for a safety and feasibility study.
Malhotra A, Novak I, Miller SL, Jenkin G. BMJ Open. 2020 May 11;10(5):e036065. doi: 10.1136/bmjopen-2019-036065. PMID: 32398336 Free PMC article.
- Is Umbilical Cord Blood Therapy an Effective Treatment for Early Lung Injury in Growth Restriction?
Allison BJ, Youn H, Malhotra A, McDonald CA, Castillo-Melendez M, Pham Y, Sutherland AE, Jenkin G, Polglase GR, Miller SL. Front Endocrinol (Lausanne). 2020 Mar 3;11:86. doi: 10.3389/fendo.2020.00086. eCollection 2020. PMID: 32194502 Free PMC article.
- Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs : UCBCs for perinatal brain injury.
Malhotra A, Castillo-Melendez M, Allison BJ, Sutherland AE, Nitsos I, Pham Y, McDonald CA, Fahey MC, Polglase GR, Jenkin G, Miller SL. Stem Cell Res Ther. 2020 Jan 8;11(1):17. doi: 10.1186/s13287-019-1526-0. PMID: 31915068 Free PMC article.
- Intranasal Delivery of Mesenchymal Stromal Cells Protects against Neonatal Hypoxic⁻Ischemic Brain Injury.
McDonald CA, Djuliannisaa Z, Petraki M, Paton MCB, Penny TR, Sutherland AE, Castillo-Melendez M, Novak I, Jenkin G, Fahey MC, Miller SL. Int J Mol Sci. 2019 May 17;20(10):2449. doi: 10.3390/ijms20102449. PMID: 31108944 Free PMC article.
- Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury.
Penny TR, Sutherland AE, Mihelakis JG, Paton MCB, Pham Y, Lee J, Jones NM, Jenkin G, Fahey MC, Miller SL, McDonald CA. Front Physiol. 2019 Mar 22;10:283. doi: 10.3389/fphys.2019.00283. eCollection 2019. PMID: 30967791 Free PMC article.
- Umbilical cord blood versus mesenchymal stem cells for inflammation-induced preterm brain injury in fetal sheep.
Paton MCB, Allison BJ, Fahey MC, Li J, Sutherland AE, Pham Y, Nitsos I, Bischof RJ, Moss TJ, Polglase GR, Jenkin G, Miller SL, McDonald CA. Pediatr Res. 2019 Aug;86(2):165-173. doi: 10.1038/s41390-019-0366-z. Epub 2019 Mar 11. PMID: 30858474
- Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep.
Paton MCB, Allison BJ, Li J, Fahey MC, Sutherland AE, Nitsos I, Bischof RJ, Dean JM, Moss TJM, Polglase GR, Jenkin G, McDonald CA, Miller SL. Dev Neurosci. 2018;40(3):258-270. doi: 10.1159/000490943. Epub 2018 Sep 4. PMID: 30179864
- Preterm umbilical cord blood derived mesenchymal stem/stromal cells protect preterm white matter brain development against hypoxia-ischemia.
Li J, Yawno T, Sutherland AE, Gurung S, Paton M, McDonald C, Tiwari A, Pham Y, Castillo-Melendez M, Jenkin G, Miller SL. Exp Neurol. 2018 Oct;308:120-131. doi: 10.1016/j.expneurol.2018.07.006. Epub 2018 Jul 20. PMID: 30012511
- Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury.
McDonald CA, Penny TR, Paton MCB, Sutherland AE, Nekkanti L, Yawno T, Castillo-Melendez M, Fahey MC, Jones NM, Jenkin G, Miller SL. J Neuroinflammation. 2018 Feb 17;15(1):47. doi: 10.1186/s12974-018-1089-5. PMID: 29454374 Free PMC article.
- Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options.
McDonald CA, Fahey MC, Jenkin G, Miller SL. Pediatr Res. 2018 Jan;83(1-2):333-344. doi: 10.1038/pr.2017.236. Epub 2017 Nov 1. PMID: 28937975 Review.
- Term vs. preterm cord blood cells for the prevention of preterm brain injury.
Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Allison BJ, Bischof R, McDonald CA, Jenkin G, Miller SL. Pediatr Res. 2017 Dec;82(6):1030-1038. doi: 10.1038/pr.2017.170. Epub 2017 Aug 16. PMID: 28723885
- Preterm white matter brain injury is prevented by early administration of umbilical cord blood cells.
Li J, Yawno T, Sutherland A, Loose J, Nitsos I, Bischof R, Castillo-Melendez M, McDonald CA, Wong FY, Jenkin G, Miller SL. Exp Neurol. 2016 Sep;283(Pt A):179-87. doi: 10.1016/j.expneurol.2016.06.017. Epub 2016 Jun 16. PMID: 27317990
- Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.
Aridas JD, McDonald CA, Paton MC, Yawno T, Sutherland AE, Nitsos I, Pham Y, Ditchfield M, Fahey MC, Wong F, Malhotra A, Castillo-Melendez M, Bhakoo K, Wallace EM, Jenkin G, Miller SL. J Physiol. 2016 Mar 1;594(5):1421-35. doi: 10.1113/JP271104. Epub 2015 Dec 14. PMID: 26527561 Free PMC article.