Advancements in combating antibiotic resistance

Monash University researchers have made significant advancements in combating antibiotic resistance through various innovative studies and collaborations:

• Associate Professor Cornelia Landersdorfer from MIPS developed a QSP model to predict antibiotic resistance emergence, optimising dosing regimens and improving treatment outcomes.
• Researchers at the Monash Biomedicine Discovery Institute (BDI) discovered how Acinetobacter baumannii uses the T6SS to outcompete bacteria, providing insights into engineering new protein toxins.
• Associate Professor Mike McDonald from the School of Biological Sciences revealed molecular reverse evolution in antibiotic resistance, opening avenues for restoring antimicrobial drug effectiveness.
• A collaboration with the Wurundjeri Woi Wurrung Cultural Heritage Aboriginal Corporation led to the discovery of bacteriophages in Merri Creek that combat superbugs, emphasising ecological and partnership values.
• Dr. Francesca Short from BDI highlighted the role of consumer products in driving antimicrobial resistance, advocating for better regulation and responsible production.
• An international clinical trial coordinated by Monash Health and Monash University demonstrated the efficacy of a shorter antibiotic course, reducing resistance and healthcare costs.

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