Controlling cell behaviour – how a worm model provides a key

Monash researchers have discovered a mechanism regulating WNT - a crucial protein that controls cell behaviour.

The international team, led by Associate Professor Roger Pocock from the Monash Biomedicine Discovery Institute, have shown that an existing drug can be used to regulate the behaviour of cells by controlling WNT secretion. The study, published today in Cell Reports, reveals the previously unknown relationship between two proteins, PDI-1 and WNT, and opens the path to target the PDI-1 protein as a way to potentially control cancer progression. Read more.