Revolutionary new cholesterol drug to save lives

Professor Stephen Nicholls with a patient.

Hundreds of thousands of Australians with life-threatening high cholesterol are set to benefit from a revolutionary new pill following the successful research and trial by Professor Stephen Nicholls, Director of the Victorian Heart Institute and Victorian Heart Hospital, based at the Monash University Clayton campus.

More than 300 Australian patients with high cholesterol took part in the breakthrough four-year clinical trial involving 14,000 people in 32 countries.

Through the trial, published in the New England Journal of Medicine (NEJM) the new cholesterol-lowering drug, bempedoic acid, demonstrated the following benefits:

  • Lowered low-density lipoprotein (LDL) cholesterol, commonly referred to as ‘bad cholesterol’, by 20-25 per cent;
  • Reduced cardiovascular complications by 13 per cent;
  • Reduced heart attacks by 23 per cent; and,
  • Reduced coronary revascularisations (a procedure to open blocked arteries) by 19 per cent.

Professor Nicholls, renowned cardiologist and Director of the new Victorian Heart Hospital at Monash Health and Monash University’s Victorian Heart Institute, co-led the landmark worldwide trial.

Currently, 2.5 million Australians take statins to lower their cholesterol. Prof. Nicholls said about 20 per cent of patients on statins had tolerance issues and about 50 per cent of high-risk patients didn’t get their cholesterol down to target levels so they need other options.

“This new drug provides another option for lowering cholesterol and is particularly important for patients that cannot tolerate statins. That’s a real problem in clinical practice which limits our ability to effectively lower cholesterol in many patients,’’ Professor Nicholls said.

“It has the potential to help between 100,000 and 500,000 people in Australia.’’

Statins decrease the risk of having a stroke or heart attack because they cut down the amount of bad cholesterol in your blood. That cholesterol can make arteries narrow making it hard for blood to circulate, creating the risk of heart attack or stroke.

Statins may cause mild side effects, including headache, nausea, dizziness, diarrhea, constipation or achy muscles or joints. Rarely, statins may cause bad side effects, including confusion, memory loss, damage to your livers or high blood sugar.

The new bempedoic acid drug – currently called Nexletol – is being developed by US-based Esperion Therapeutics and will go to the Therapeutics Goods Administration for approval for use in Australia.

Professor Nicholls said he expected the drug to be available for Australian patients in the next two years.

The new world-class Victorian Heart Hospital operated by Monash Health at Monash University’s Clayton Campus is Australia’s first specialist cardiac hospital. It will offer a full range of cardiovascular services, including critical and emergency care, outpatient clinics, imaging services, and a full cardiac surgical team.

About the Victorian Heart Hospital

The Victorian Heart Hospital is the latest addition to the Monash Health group of hospitals.

In partnership with Monash University and housing the Monash Victorian Heart Institute, the Heart Hospital integrates clinical cardiology services, research and education to create a centre of excellence, raising the profile of cardiovascular research, treatment and training.

With a capacity for up to 206 beds, the Victorian Heart Hospital each year will provide 28,000 cardiac emergency patient assessments, 10,000 interventional cardiac catheterisation procedures, and 2000 open heart surgeries.

The Victorian Heart Hospital began welcoming patients from Thursday 23 February 2023. The hospital will open in a staged approach with a plan to have all clinical services operational over the coming weeks. For more information, please visit www.victorianhearthospital.org

About the Monash Victorian Heart Institute

Monash University is transforming the future of cardiovascular health – for Australia and for the world. We’re committed to shaping global knowledge about cardiovascular disease, including how to better prevent it, better detect it, and better treat it. And we’re applying this knowledge across every facet of cardiovascular care.

Across Monash we embed research, health care and discovery into our approach, and bring labside knowledge to bedside practice to drive tangible changes for patient outcomes for the betterment of all communities.

The Monash Victorian Heart Institute reflects our University-wide commitment to collaborative heart health solutions. We are focused on delivering excellence in research, education and training, to change the prevalence of cardiovascular disease in Australia.

For more information, please visit www.monash.edu/research/vic-heart-institute

About Monash Health

Monash Health is Victoria’s largest public health service. We provide safe, high-quality care to one-quarter of Melbourne’s population, across the entire lifespan, from pre-birth to end of-life. For more information, please visit www.monashhealth.org