Dr. Josie Carberry

Dr. Josie Carberry

Lecturer
Department of Mechanical and Aerospace Engineering
Room 312, 20 Research Way (Building 82), Clayton Campus

Dr.Josie, overall theme of research is developing methods to measure and understand flow induced mechanotransduction. Her research expertise is largely focused on blood flow and the effects of these flows on cell function in both healthy and disease states. She has contributed in development of number of techniques directly focused on biomedical applications,

4D measurements of shearing stress and pressure.

High resolution 4D measurements of evolving geometries e.g. thrombosis / embolism.

Exploiting combinations of in-vitro/vivo imaging and computational techniques to make measurements are not possible using individual techniques.

Development of methods to mimic physiological and pathological flow conditions in micro-fluidic devices.

Computational and image processing techniques to detect and explore correlations between different types of data sets.

Her current project is determining the links between the shearing stress experienced by platelets and subsequent thrombus growth, thrombus stability and molecular activity and have conducted in-vitro experiments to image the growing thrombus in real time capturing both the geometry of the thrombus and pertinent biological markers. And then reconstruct the thrombus geometry from the images. The speed of thrombus growth requires to develop a technique to correct for growth occurring during the acquisition of each z-stack. The flow over the thrombus is then simulated numerically to capture flow field properties such as velocity and shear stress. This gives the ability to correlate 4D flow properties with the real time properties of the thrombus, including biological activity and growth (thrombosis/embolism).

Qualifications

  • Postdoc, Biomedical Engineering., Georgia Institute of Technology.
  • PhD, Mechanical Engineering., Monash University.

Research Projects

Past projects

Biomedical Engineering Sensing and Imaging Facility

A major facility in biomedical engineering sensing and imaging is proposed. It will foster multi discipline teams of medical and engineering researchers to develop innovative processes and technology for the prevention, diagnosis, and treatment of disease, for patient rehabilitation, and for improving health. The new facility will build on a number of existing research strengths and resources across the participating universities as well as the CSIRO and hospital-based research groups.

Supersonic flow past micro-scale particles: Industrial applications

Droplet-based materials processing is a method currently used in the manufacture of light-weight, high-strength metal alloys for use in a wide range of industries. Critical to the successful use of such processes is an accurate knowledge of the cooling rate of micro-sized droplets within high speed flows, with velocities greater than the speed of sound. Current understanding of the cooling rate relies upon empirical knowledge. This project intends to provide world first, highly-accurate numerical and experimental research to determine the thermo- and fluid-dynamics for flows around micro-scale spheres. The overall aim of this project is to determine an accurate model for the cooling rate of droplets in high-speed flows.

Publications

Nesbitt, W.S., Westein, E., Lopez, F.J.T., Tolouei, E., Mitchell, A., Fu, J., Carberry, J., Fouras, A. & Jackson, S.P. (2009) A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nature Medicine 15, 665-673, doi:10.1038/nm.1955

Tolouei, E., Butler, C.J., Fouras, A., Ryan, K., Sheard, G.J. & Carberry, J. (2011) Effect of hemodynamic forces on thrombi geometry. Annals of Biomedical Engineering, 39 (5), 1403-1413 doi: 10.1007/s10439-010-0239-4

Simon, H.A., Leo, H.L., Carberry, J. & Yoganathan, A.P. (2004) Comparison of the hinge flow fields of two bileaflet mechanical heart valves under aortic and mitral conditions. Annals of Biomedical Engineering 32 (12), 1607-1617, doi:10.1007/s10439-004-7814-5

MIME Theme

Bio fluids, rheology, micro fluids, lab-on-a-chip, imaging, numerical flow simulations, bio mechanics, cardiovascular, mechanobiology.

Teaching Commitments

  • MEC2404 - Mechanics of fluids.
  • MAE1041 - Introduction to Aerospace Engineering Workload.
  • MEC3465 - Fluid Mechanics (BE (Mechanical).
  • MAE3469 - Computer-Assisted Engineering.
Last modified: 11/05/2020