Mr. Prabhakar Ranganathan

Dr. Prabhakar Ranganathan

Senior Lecturer
Department of Mechanical and Aerospace Engineering
Room 325, 20 Research Way (Building 82), Clayton Campus

Prabhakar works at the Department of Mechanical and Aerospace Engineering in the Faculty of Engineering at Monash University as a Senior Lecturer.

He is interested in understanding how cells exploit mechanics — motion and forces — to their advantage. Such understanding could lead to novel medical applications or to the development of biomimetic devices and processes.

For instance, Prabhakar is working with Moira O’ Bryan in the Faculty of Medicine to understand how a mammalian sperm cell in uses their tail (flagellum) to navigate through the complex fluid environment in an oviduct to reach and fertilize an egg. Male infertility is an emerging issue not only in men, but for farmers, animal breeders and conservation efforts. This study will help design new methods of assessment and treatment of male infertility. Understanding flagellar propulsion could also enable the design of artificial filaments for pumping and mixing fluids in microfluidic devices. Besides sperm cells, Prabhakar’s group also studies the mechanics of amoeboid locomotion of animal cells on surfaces, and the collective migration of infectious bacteria on surfaces.

Prabhakar uses mathematical modeling and computer simulations to relate the observed motion and behaviour in such systems to their complex mechanical properties, internal forcing by protein motors, and biochemical and genetic regulation. He collaborates with other groups on experiments to validate these models.

 

Qualifications

  • B Tech, Chemical Engineering, Indian Institute of Technology Madras.
  • MS, Chemical Engineering, Indian Institute of Technology Madras.
  • Ph.D, Chemical Engineering, Monash University.

Expertise

Mechanobiology of microbial motility in complex environments.
Fluid-structure interactions in flagella and cilia and their biochemical regulation.
Cytoskeleton-driven amoeboid locomotion of cells on surfaces.
Bio-inspired soft devices for microfluidic mixing and pumping.
Rheology, microstructural constitutive models and non-Newtonian fluid mechanics of viscoelastic polymer solutions and complex interfaces.
Particle-based simulation methods for complex fluids e.g. Smoothed Dissipative Particle Dynamics.
Mesoscopic simulation methods such as Brownian Dynamics, Dissipative Particle Dynamics and Stokesian Dynamics.
Computational Fluid Dynamics.
Sperm function.
Microfluidics.

Supervision interests

Mechanobiology of microbial motility in complex environments.

Fluid-structure interactions in flagella and cilia and their biochemical regulation.

Cytoskeleton-driven amoeboid locomotion of cells on surfaces.

Bio-inspired soft devices for microfluidic mixing and pumping.

Rheology, microstructural constitutive models and non-Newtonian fluid mechanics of  viscoelastic polymer solutions and complex interfaces.

Particle-based simulation methods for complex fluids e.g. Smoothed Dissipative Particle Dynamics.

Mesoscopic simulation methods such as Brownian Dynamics, Dissipative Particle Dynamics and Stokesian Dynamics.

Community Service

Participant in the Scientists-in-Schools program.(www.scientistsinschools.edu.au).

Professional Association

Council member, Australian Society of Rheology.
Member, Society of Rheology.

Research Projects

Past projects

Designing polymer additives to control breakup of jets and impacting drops.

In agricultural spraying, pesticide is wasted as a fine mist, or because drops rebound off leaf surfaces, causing serious soil and water pollution. Small amounts of polymeric additives can add elasticity to sprayed liquids that greatly suppress these problems. We combine decades of expertise at Monash and MIT on the flow behavior of dilute polymer solutions to investigate how chemistry, structure and concentration of such additives can be designed to control a spray-and-deposit process. This study will help to significantly reduce the serious environmental impact of pesticide wastage in agricultural spraying.

2017

Effect of stretching-induced changes in hydrodynamic screening on coil-stretch hysteresis of unentangled polymer solutions.

Ranganathan, P., Sasmal, C., Nguyen, D. A., Sridhar, T. & Prakash, J. R. 5 Jan 2017 In : Physical Review Fluids. 2, 1, 8 p., 011301(R).

2016

Influence of stretching induced self-concentration and self-dilution on coil-stretch hysteresis and capillary thinning of unentangled polymer solutions.

Prabhakar, R., Gadkari, S., Gopesh, T. & Shaw, M. J. 1 May 2016 In : Journal of Rheology. 60, 3, p. 345-366 22 p.

2015

Extensional viscosity of copper nanowire suspensions in an aqueous polymer solution

McDonnell, A. G., Jason, N. N., Yeo, L. Y-M., Friend, J. R., Cheng, W. & Ranganathan, P. 2015 In : Soft Matter. 11, 41, p. 8076 – 8082 7 p.

Motility induced changes in viscosity of suspensions of swimming microbes in extensional flows.

McDonnell, A. G., Tilvawala, G. C., Lo, C. Y. J., O’Bryan, M. K., Yeo, L. Y-M., Friend, J. R. & Ranganathan, P. 2015 In : Soft Matter. 11, 23, p. 4658 – 4668 11 p.

Significance of thermal fluctuations and hydrodynamic interactions in receptor-ligand-mediated adhesive dynamics of a spherical particle in wall-bound shear flow.

Ramesh, K. V., Thaokar, R., Jagadeeshan, R. P. & Ranganathan, P. 2015 In : Physical Review E – Statistical, Nonlinear, and Soft Matter Physics. 91, 2, p. 1 – 12 12 p.

2013

Self-organization of bacterial biofilms is facilitated by extracellular DNA.

Gloag, E. S., Turnbull, L., Huang, A., Vallotton, P., Wang, H., Nolan, L., Mililli, L., Hunt, C. J., Lu, J., Osvath, S., Monahan, L., Cavaliere, R., Charles, I., Wand, M. P., Gee, M., Ranganathan, P. & Whitchurch, C. B. 2013 In : Proceedings of the National Academy of Sciences. 110, 28, p. 11541 – 11546 6 p.

2011

A new empirical viscosity model for ceramic suspensions.

Amini Horri, B., Ranganathan, P., Selomulya, C. & Wang, H. 2011 In : Chemical Engineering Science. 66, 12, p. 2798 – 2806 9 p.

ADMiER-ing thin but complex fluids.

McDonnell, A. G. M., Bhattacharjee, P. K., Pan, S., Hill, D., Danquah, M., Friend, J., Yeo, L. & Prabhakar, R. 2011 Proceedings of the SPIE – Smart Nano-Micro Materials and Devices: 5–7 December 2011, Hawthorn, Australia. Juodkazis, S. & Gu , M. (eds.). Bellingham, Washington: SPIE, 7 p. 82040I. (SPIE – International Society for Optical Engineering. Proceedings; vol. 8204).

Effect of helicity on wrapping and bundling of semi-flexible filaments twirled in a viscous fluid.

Clark, S. A. & Ranganathan, P. 2011 In : Soft Matter. 7, p. 5536 – 5539 4 p.

Extensional flow of low-viscosity fluids in capillary bridges formed by pulsed surface acoustic wave jetting.

Bhattacharyya, P., McDonnell, A., Ranganathan, P., Yeo, L. & Friend, J. 2011 In : New Journal of Physics. 13, p. 1 – 14 14 p.

Micro-rheology near fluid interfaces.

Wang, G., Ranganathan, P., Gao, Y. & Sevick, E. 2011 In : Journal of Optics. 13, 4, p. 1 – 7 7 p.

2009

Hydrodynamic mobility of an optically trapped colloidal particle near fluid-fluid interfaces.

Wang, G., Ranganathan, P. & Sevick, E. 2009 In : Physical Review Letters. 103, 24, p. 1 – 4 4 p.

Segmentation and tracking individual pseudomonas aeruginosa bacteria in dense populations of motile cells.

Vallotton, P., Sun, C., Wang, D., Turnbull, L., Whitchurch, C. & Ranganathan, P. 2009 24th International Conference Image and Vision Computing New Zealand, IVCNZ 2009 – Conference Proceedings. p. 221-225 5 p. 5378409.

2008

Coarse-Graining Hydrodynamic Interactions in Isolated Polymer Molecules in Solution.

Ranganathan, P. 2008 Proceedings of the XXII International Congress on Theoretical and Applied Mechanics. Denier, J., Finn, M. & Mattner, T. (eds.). Adelaide SA Australia: ICTAM, p. 1 – 2 2 p.

Evaluation of the Gaussian Blob Model for Coarse-Graining Hydrodynamic Interactions in Isolated Polymer Molecules.

Ranganathan, P. 2008 Proceedings of the XVth Internatinal Congress on Rheology, AP Conference Proceedings. Co, A., Leal, L. G., Colby, R. H. & Giacomin, A. J. U. (eds.). New York, USA: American Institute of Physics, Vol. 1027, p. 309 – 311 3 p.

Fluctuation Theorems.

Sevick, E. M., Ranganathan, P., Williams, S. R. & Searles, D. J. 2008 In : Annual Review of Physical Chemistry. 59, p. 603 – 633 31 p.

2007

Coarse-graining intramolecular hydrodynamic interaction in dilute solutions of flexible polymers.

Ranganathan, P., Sevick, E. M. & Williams, D. R. M. 2007 In : Physical Review E – Statistical, Nonlinear, and Soft Matter Physics. 76, 1, p. 011809-1 – 011809-12 12 p.

Rheological observation of glassy dynamics of dilute polymer solutions near the coil-stretch transition in elongational flows.

Sridhar, T., Nguyen, D. A., Ranganathan, P. & Jagadeeshan, R. P. 2007 In : Physical Review Letters. 98, 16, p. 16 – 20 5 p.

2006

Effect of configuration-dependent intramolecular hydrodynamic interaction on elastocapillary thinning and breakup of filaments of dilute polymer solutions.

Prabhakar, R.Prakash, J. R. & Sridhar, T. 2006 In : Journal of Rheology. 50, 6, p. 925 – 947 23 p.

Gaussian approximation for finitely extensible beadspring chains with hydrodynamic interaction

Prabhakar, R. & Jagadeeshan, R. P. 2006 In : Journal of Rheology. 50, 4, p. 561 – 593 33 p.

2005

A fast and accurate model for predicting the behaviour of dilute polymer solutions in complex flows.

Prabhakar, R. & Jagadeeshan, R. P. 2005 Proceedings of CHEMECA 2005. Brisbane Qld Australia: Institution of Engineers Australia, p. 1 – 6 6 p.

2004

A successive fine-graining scheme for predicting the rheological properties of dilute polymer solutions.

Ranganathan, P.Jagadeeshan, R. P. & Sridhar, T. 2004 In : Journal of Rheology. 48, 6, p. 1251 – 1278 28 p.

Exploring the universal dynamics of dilute polymer solutions in extensional flows.

Ranganathan, P., Sunthar, P. & Jagadeeshan, R. P. 2004 In : Physica A: Statistical Mechanics and its Applications. 339, 1-2, p. 34 – 39 6 p.

Fast and accurate closure approximations for bead-spring models of dilute polymer solutions.

Ranganathan, P. & Jagadeeshan, R. P. 2004 In : ANZIAM Journal. 46, 5 ELECTRONIC SUPPL., p. C379 – C393 15 p.

Modelling the stress-conformational hysteresis in uniaxial extensional flows of dilute polymer solutions.

Ranganathan, P. & Jagadeeshan, R. P. 2004 Proceedings of the XIVth International Conference on Rheology. Lee, J. W. & Lee, S. J. (eds.). Seoul South Korea: The Korean Society of Rheology, p. MS18-1 – MS18-3 3 p.

Rescaling of excluded volume and hydrodynamic interaction parameters in bead spring chain models with finitely extensible springs.

Sunthar, P., Ranganathan, P. & Jagadeeshan, R. P. 2004 Proceddings of the XIVth International conference on Rheology. Lee, J. W. & Lee, S. J. (eds.). Seoul South Korea: The Korean Society of Rheology, p. PS08-1 – PS08-3 3 p.

2003

Multiplicative separation of the influences of excluded volume, hydrodynamic interactions and finite extensibility on the rheological properties of dilute polymer solutions.

Ranganathan, P. & Jagadeeshan, R. P. 2003 In : Journal of Non-Newtonian Fluid Mechanics. 116, 2-3, p. 163 – 182 20 p.

2002

Rheological behaviour of FENE dumbbells with excluded volume interactions in simple shear and uniaxial extensional flows.

Ranganathan, P. & Jagadeeshan, R. P. 2002 Proceedings of the 9th APCChe Congress and CHEMECA 2002. Gostomski, P. A. & Morison, K. R. (eds.). Christchurch New Zealand: University of Canterbury, p. 428 – 446 19 p.

Viscometric functions for hookean dumbbells with excluded volume and hydrodynamic interactions.

Ranganathan, P. & Jagadeeshan, R. P. 2002 In : Journal of Rheology. 46, 5, p. 1191 – 1220 30 p.

 

 

Supervision

PHD

Sarah Clark

Amarin McDonnell

Ramesh Kavali

Nikhil Srivastav

Research fellow

Anuja Mehrotra

Postgraduate

Gopesh Tilvawala

Teaching Commitments

  • MEC3451 - Fluid mechanics 2.
  • MEC6410 - Research Practices.
  • MEC4447 - Computers in Fluids and Energy.
Last modified: July 18, 2018