Dr. Reza Nosrati

Dr. Reza Nosrati

Lecturer
Department of Mechanical and Aerospace Engineering
Room 219, 20 Research Way (Building 82), Clayton Campus

Dr. Nosrati’s research focuses on small-scale fluid mechanics (microfluidics and nanofluidics), with applications in cell biology, translational medicine, chemistry, and environmental science. He is a pioneer in microfluidics for male fertility and assisted reproduction. He has authored papers in top-tier scientific journals like Nature Communications, Nature Reviews Urology, Clinical Chemistry, and Lab on a Chip. His work has been highlighted several times in renowned journals such as Nature Reviews Urology, and featured routinely in news sources worldwide, including LA Times, Daily Mail, and The Scientist.

Dr. Nosrati has received numerous prestigious awards and recognitions, including an NSERC Postdoctoral Fellowship, a Research Discovery Award from the University of Toronto, the 2016 Douglas R. Colton Medal for research excellence in Microsystems and Nanotechnology in Canada, and the 2018 ROYAN International Research Award for outstanding contributions to Embryology and Andrology.

For information on available projects and openings, please visit the Applied Microfluidics and Bioengineering (AMB) Lab.

Qualifications

  • Ph.D. in Mechanical Engineering, University of Toronto
  • M.Sc. in Mechanical Engineering, University of Tehran
  • B.Sc. in Mechanical Engineering, Amirkabir University of Technology

Research Interests

Fluidics for Health and the Environment

We engineer innovations for understanding biological systems at the single-cell level, and then we apply this knowledge to develop novel biomedical technologies for applications in health and environmental science. We combine our knowledge of microfluidics, optics, advanced microscopy, electrokinetics, cell biology, and translational medicine to carefully mimic, manipulate, and measure biology. The current areas of focus include sperm motility, Infertility, assisted reproduction, organ-on-a-chip, cancer diagnostics, microbe-based environmental remediation, and climate change. Some examples of our current and past research areas are listed below. Please visit the Applied Microfluidics and Bioengineering (AMB) Lab for more information. 

Fertility

We are developing innovative microfluidic technologies for advanced understanding of fertilisation and studying the reproductive future of patients after cancer survival, with the potential to devise new diagnostic and therapeutic methods for infertility and oncofertility. This research program will produce state-of-the-art technologies for pharmaceutical applications in assisted reproduction and drug discovery.

 

 

 

Cell Motility

We are developing new methods to resolve the swimming characteristics of microswimmers, including sperm and bacteria, in confined environments and to understand their interaction mechanisms with physiochemical stimuli present in vivo or in their natural habitats. 

 

 

 

 

Diagnostics

We are developing microfluidic technologies, particularly in paper-based formats, paired with emerging mobile health strategies for clinical and point-of-care diagnostics. This research program will result in simple, rapid, and low-cost platforms to offer new possibilities for accurate and early diagnosis and prevention of current health threats, such as cancer and infectious diseases.

 

 

 

 

 

Sensing

We are developing simple and low-cost biosensors for rapid and ultrasensitive detection of biochemical analytes. These sensing methods can directly detect trace concentrations of drugs, explosives, and pesticides, suitable for broad applications in environmental monitoring, forensic science, and medical diagnostics.

Refereed Journal Publications

17. Rismani Yazdi, R. Nosrati, C. Stevens, D. Vogel, P. Davies, C. Escobedo (2018) Magnetotaxis enables magnetotactic bacteria to navigate in flow. Small 14, 1702982.

[Featured on the front cover of this issue]

[Featured in Phys.org, EurekAlert, Science Daily, Nanowerk, and Queen’s gazette]

16. Dies*, R. Nosrati*, J. Raveendran, C. Escobedo, A. Docoslis (2018) SERS-from-scratch: an electric field-guided nanoparticle assembly method for cleanroom-free and low-cost preparation of surface-enhanced Raman scattering substrates. Colloids and Surfaces A: Physicochemical and Engineering Aspects 553, 695-702. * Authors contributed equally

15. Rismani Yazdi, R. Nosrati, C. Stevens, D. Vogel, C. Escobedo (2018) Migration of magnetotactic bacteria in porous media. Biomicrofluidics 12, 011101.

14. Nosrati, P. J. Graham, B. Zhang, J. Riordon, A. Lagunov, T. G. Hannam, C. Escobedo, K. A. Jarvi, D. Sinton (2017) Microfluidics for sperm analysis and selection. Nature Reviews Urology 14, 707-730.

[Featured on the home page of Nature Reviews Urology, December 2017]

[Top-6 Most Read Articles in Nature Reviews Urology in December 2017]

13. Nosrati, M. M. Gong, M. C. San Gabriel, A. Zini, D. Sinton (2016) Paper-based sperm DNA integrity analysis. Analytical Methods 8, 6260-6264.

[Featured on the front cover of this issue]

12. Nosrati, P. J. Graham, Q. Liu, D. Sinton (2016) Predominance of sperm motion in corners. Scientific Reports 6, 26669.

11. Eamer*, M. Vollmer*, R. Nosrati*, M. C. San Gabriel, K. Zeidan, A. Zini, D. Sinton (2016) Turning the corner in fertility: high DNA integrity of boundary-following sperm. Lab on a Chip 16, 2418-2422. * Authors contributed equally

[Featured on the inside front cover of this issue]

10. Nosrati, M. M. Gong, M. C. San Gabriel, Claudio E. Pedraza, A. Zini, D. Sinton (2016) Paper-based quantification of male fertility potential. Clinical Chemistry 62, 458-465.

[Featured in Editorial “Toward a microfluidics-based home male fertility test”, Clinical Chemistry 62, 421 (2016)]

[Featured in CSME Bulletin, ‘Paper-based device may lead to a home male infertility test’, Fall Issue (2016)]

[Featured in Daily Mail UK, The Sun, and Pembe Nar (Turkish)]

9. Nosrati, A. Driouchi, C. M. Yip, D. Sinton (2015) Two-dimensional slither swimming of sperm within a micrometre of a surface. Nature Communications 6, 8703.

[Highlighted in Nature Reviews Urology, ‘Just keep swimming — sperm exhibit a 2D slither motion’,13, 2 (2016)]

[Featured in over 20 public news media worldwide including The Scientist, Tech Times, LA Times, Daily Mail UK, MSN News, The Star, Popular Science, The Sun, slate (French), Lentra (Russian), bild der wissenschaft (German), sina (Chinese), Nature Communications Press Release, and nature asia]

8. M. Gong, R. Nosrati, M. C. San Gabriel, A. Zini, D. Sinton (2015) Direct DNA analysis with paper-based ion concentration polarization. Journal of the American Chemical Society 137, 13913-13919.

[Highlighted in ACS PressPac, Chemical & Engineering News, Science Daily, EurekAlert, Medical News Today, Health Medicinet, and The Medical News]

7. Eamer*, R. Nosrati*, M. Vollmer, A. Zini, D. Sinton (2015) Microfluidic assessment of swimming media for motility-based sperm selection. Biomicrofluidics 9, 044113. * Authors contributed equally

6. Nosrati, M. Vollmer, L. Eamer, M. C. San Gabriel, K. Zeidan, A. Zini, D. Sinton (2014) Rapid selection of sperm with high DNA integrity. Lab on a Chip 14, 1142-1150.

5. Nosrati, M. Hadigol, M. Raisee, A. Nourbakhsh (2012) Numerical modeling of electroosmotic nanoflows with overlapped electric double layer. Journal of Computational and Theoretical Nanoscience 9, 2228-2239.

4. Hadigol, R. Nosrati, M. Raisee (2011) Numerical analysis of mixed electroosmotic/pressure driven flow of power-law fluids in microchannels and micropumps. Colloids and Surfaces A: Physicochemical and Engineering Aspects 374, 142-153.

3. Hadigol, R. Nosrati, A. Nourbakhsh, M. Raisee (2011) Numerical study of electroosmotic micromixing of non-Newtonian fluids. Journal of Non-Newtonian Fluid Mechanics 166, 965-971.

2. Nosrati, M. Hadigol, A. Jafari, M. Raisee, A. Nourbakhsh (2011) Numerical investigation of electroosmotic mixing in microchannels with heterogeneous zeta potential. Advanced Science, Engineering and Medicine 3, 253-261.

1. Nosrati, M. Hadigol, M. Raisee (2010) The effect of Y-component electroosmotic body force in mix electroosmotic/pressure driven microflows. Colloids and Surfaces A: Physicochemical and Engineering Aspects 372, 190-195.

 

Patents and Invention Disclosures

6. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Apparatus and method for sperm separation. U.S. Patent No. 14/547,606, Canada Patent No. 2834007, Brazilian Patent Application No. BR102014028937, May 30, 2017.

5. Nosrati, M. M. Gong, D. Sinton. Devices and methods for quantification of male fertility. U.S. and Canadian National Patent Application No. 62/258,178, filed November 20, 2015.

4. M. Gong, R. Nosrati, D. Sinton. Devices and methods for nucleic acid detection. U.S. Provisional Patent Application No. 62/258,242, filed November 20, 2015.

3. Nosrati, M. M. Gong, D. Sinton. Quantitative semen analysis in paper-based microfluidic assays. University of Toronto Confidential Invention Disclosure #10003012, filed October 14, 2015.

2. M. Gong, R. Nosrati, D. Sinton. Nucleic acid analysis in paper-based assays with ion concentration polarization. University of Toronto Confidential Invention Disclosure #10003013, filed October 14, 2015.

1. Nosrati, L. Eamer, M. Vollmer, D. Sinton. High-throughput sperm separation device for the use in Artificial Reproductive Technologies (ARTs). University of Toronto Confidential Invention Disclosure #10002635, filed July 18, 2013.

 

Fully Refereed Conference Proceedings

4. Nosrati, P.J. Graham, D. Sinton. Corner accumulation behavior of spermatozoa in microchannels. 4th Micro and Nano Flows Conference (MNF2014), London, UK, September 7-10, 2014. Editors C.S. König, T.G. Karayiannis and S. Balabani, ISBN 978-1-908549-16-7.

3. Nosrati, A. Driouchi, C.M. Yip, D. Sinton. Analyzing near wall sperm motion using TIRF microscopy. Proceedings of The Canadian Society for Mechanical Engineering International Congress 2014 (CSME 2014), CSME2014-104920, Toronto, Canada, June 1-4, 2014.

2. Nosrati, M. Raisee, A. Nourbakhsh. Modeling of electroosmotic nanoflows with overlapped double layer. Proc. ASME. 44649; ASME 2011 9th International Conference on Nanochannels, Microchannels, and Minichannels, vol. 2 :265-276, ICNMM2011-58087, Edmonton, Canada, June 19-22, 2011.

1. M. Hadigol, S. Keshavarz, R. Nosrati. An evaluation of different configurations of organic Rankine cycles ‘ORC’, by considering thermal and second law efficiencies and minimum irreversibility. 6th ISME STU 2009, ASCME06_012, Tehran, Iran, March 2009.

 

Selected Conference Abstracts and Presentations

17. Dies, J. Raveendran, R. Nosrati, C. Escobedo, A. Docoslis. Identification and quantification of illicit drugs using nanodendritic surface-enhanced Raman scattering substrates. 29th Interamerican Congress of Chemical Engineering incorporating the 68th Canadian Chemical Engineering Conference, Toronto, Canada, October 28-31, 2018.

16. Zhang, R. Nosrati, L. Maghen, A. Lagunov, T.G. Hannam, D. Sinton. Paper-based quantification of human sperm DNA fragmentation. 62nd Annual Meeting of Canadian Fertility and Andrology Society (CFAS), Toronto, Canada, September 22-24, 2016.

15. Zeidan, M. C. San Gabriel, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Rapid selection of motile sperm with high DNA integrity using microfluidics. American Society of Andrology 40th Annual Conference, Salt Lake City, UT, April 18-21, 2015.

14. C. San Gabriel, K. Zeidan, K. Alrabeeah, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Comparative study of microfluidic device (MFD) and density gradient centrifugation (DGC) in selecting sperm with high DNA integrity. American Society of Andrology 40th Annual Conference, Salt Lake City, UT, April 18-21, 2015.

13. Zeidan, M. San Gabriel, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Rapid selection of motile sperm with high DNA integrity using microfluidics. 60th Annual Meeting of the Canadian Fertility and Andrology Society (CFAS), Quebec City, Canada, September 11-14, 2014.

12. San Gabriel, K. Zeidan, K. Alrabeeah, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Comparative study of microfluidic device (MFD) and density gradient centrifugation (DGC) in selecting sperm with high DNA integrity. 60th Annual Meeting of the Canadian Fertility and Andrology Society (CFAS), Quebec City, Canada, September 11-14, 2014.

11. Nosrati, A. Driouchi, C.M. Yip, D. Sinton. Near-surface sperm hydrodynamics using TIRF microscopy. 9th Ontario-on-a-Chip Symposium (OOAC9/MATCH), Toronto, Canada, May 29-30, 2014.

10. Nosrati, A. Driouchi, K.J. Downie, A. Vissa, C.M. Yip, D. Sinton. Near-surface hydrodynamics of spermatozoa by total internal reflection fluorescence microscopy. 1stinternational conference on Micro & Nanofluidics (Flow14), Enschede, The Netherlands, May 18-21, 2014.

9. Zeidan, R. Nosrati, L. Eamer, M. Vollmer, M. San Gabriel, D. Sinton, A. Zini. High-throughput microfluidic device for motile sperm selection. American Society of Reproductive Medicine (ASRM) 69th Annual Meeting in Fertility and Sterility 100 (3), S220, Boston, MA, October 12-17, 2013.

8. Eamer, R. Nosrati, M. Vollmer, D. Sinton. Microfluidics separation of sperm based on total progressive motility. 4th Annual MIE Research Symposium 2013, Toronto, Canada, June 10, 2013.

7. Nosrati, L. Eamer, M. Vollmer, D. Sinton. High-throughput viable sperm separation on-a-chip with milliliter-scale sample capacity. 4th Annual MIE Research Symposium 2013, Toronto, Canada, June 10, 2013.

6. Nosrati, K. Zeidan, M. Vollmer, L. Eamer, M. San Gabriel, A. Zini, D. Sinton. Viable sperm separation on-a-chip with millilitre-scale sample capacity. Advances in Microfluidics & Nanofluidics (AMN), Notre Dame, IN, May 24-26, 2013.

5. Potyrailo, D. Sinton, Y. Lee, R. Nosrati. Toward rapid detection of biological particles using multivariable resonant label-free biosensors. 245th ACS National Meeting & Exposition, New Orleans, LA, April 7-11, 2013.

4. Nosrati, M. Vollmer, L. Eamer, K. Zeidan, M. San Gabriel, A. Zini, D. Sinton. Microfluidic separation of motile sperm with millilitre-scale sample capacity. 65th Annual Meeting of the American Physical Society’s Division of Fluid Dynamics (DFD), San Diego, CA, November 18-20, 2012.

3. Nosrati, M. Vollmer, L. Eamer, D. Sinton. Millilitre-scale sperm sorting for assisted reproductive technology (ART). 2nd Annual MIE Research Symposium 2012, Toronto, Canada, June 4, 2012.

2. Eamer, M. Vollmer, R. Nosrati, D. Sinton. Microfluidic separation of sperm based on total progressive motility in high viscosity media. 2nd Annual MIE Research Symposium 2012, Toronto, Canada, June 4, 2012.

1. Vollmer, R. Nosrati, L. Eamer, D. Sinton. High-throughput sperm motility assay and automated selection for clinical in vitro fertilization. 7th Ontario-on-a-Chip Symposium (OOAC7/MATCH), Toronto, Canada, May 17-18, 2012.

Last modified: 24/10/2019