Wagstaff Lab research
About Dr Kylie Wagstaff
Dr Kylie Wagstaff, Ph.D., is a National Breast Cancer Foundation Career Development Fellow within the Department of Biochemistry and Molecular Biology at Monash University (Melbourne) and Head of the Cancer Targeting and Nuclear Therapeutics Laboratory. She got her B.Biomed.Sci. and her Ph.D. in Biochemistry at Monash University (Melbourne). Her research over the last 18 years has focused on the regulation of transport into and out of the eukaryotic cell nucleus, and how this relates to viral disease, cancer and development. She has c. 40 peer-reviewed publications (>1,000 citations; H-factor of 18). Her awards and prizes include National Breast Cancer Foundation, Career Development Fellowship (2017), the International Union of Biochemistry and Molecular Biology (IUBMB) Young Scientist Program Prize (2009) and the Caroline Chisholm award for service (2015).
- Advanced tumour targeting agents for triple-negative breast cancer.
- The role of nuclear transport in cellular stress, DNA damage and repair.
- Novel anti-viral agents targeting nuclear transport.
Visit Dr Kylie Wagstaff's Monash research profile to see a full listing of current projects.
Research interests: Transport of proteins between the cytoplasm and nucleus and the application of this to diseases including cancer and viral infection.
Breast cancer remains one of the leading causes of death in Australia, with current treatments often causing debilitating unwanted toxic side effects. By determining the underlying cellular differences between cancer and normal cells, we are able to understand the causes of these changes and to develop new drugs and delivery agents to target them specifically.
Similarly, infectious diseases such as those caused by viruses and cellular stress conditions often rely upon or generate changes in the subcellular targeting of various proteins, particularly those involved in transport between the cytoplasm and the nucleus. We identify these protein interactions and harness them to develop novel anti-viral drugs and to uncover the cellular pathways, which underpin these important conditions.
Laser activated, tumour targeting drug delivery particles.
Specific drug release (green) after laser activation occurs in tumour cells only.
We collaborate with many scientists and research organisations around the world. Click on the map to see the details for each of these collaborators (dive into specific publications and outputs by clicking on the dots).
Student research projects
The Wagstaff Lab offers a variety of Honours, Masters and PhD projects for students interested in joining our group. There are also a number of short term research opportunities available.
Please visit Supervisor Connect to explore the projects currently available in our Lab.