Early Career Research Publication Award

This Award recognises excellence in research publication, for researchers with up to 5 years of experience post-PhD.

2020 Paulina Ramirez-Garcia

Paulina was awarded for the following publication where she contributed to more than 70% of the figures: Ramírez-García, P.D., Retamal, J.S., Shenoy, P. et al. A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain. Nat. Nanotechnol. 14, 1150–1159 (2019). https://doi.org/10.1038/s41565-019-0568-x

This work demonstrates how information on receptor trafficking and signalling can be utilised to design drug delivery systems to direct drugs to the appropriate location that may improve clinical success, and in the case of aprepitant, improve pain relief.

The publication was the culmination of more than 3 years of multi-disciplinary research, performed entirely during Paulina's PhD. With co-supervision of Dr Nicholas Veldhuis, Prof Tom Davis (D4, CBNS) and Prog Nigel Bunnett (DDB) it is a great example of a MIPS cross-theme collaborative study and involved international partners from Australia, Chile and the USA.