Program
SUNDAY June 17
2.00pm Registration
3.00pm Conference Opening Lecture
Cardiovascular diseases and drugs: where are we with hiPSC models?
Christine Mummery (Leiden University Medical Center, The Netherlands)
4.00pm Short oral communications
Distinct microglial subtypes in Alzheimer's disease are induced by plaque phagocytosis.
Alexandra Grubman (Monash University)
Expression of TRP channels in human bone marrow-derived MSCs, stromal vascular fraction (SVF) progenitors and after differentiation into white or brown adipocytes
Anna Goralczyk (National University of Singapore, Singapore)
The Fight MND Drug Screening Program: Large-scale generation of patient derived iPS lines to identify candidate therapeutics for Motor Neuron Disease
Chris Bye (University of Melbourne)
Integrative molecular analyses reveal distinct reprogramming trajectories into states of naïve and primed human induced pluripotency?
(Ethan) Xiaodong Liu (Monash University)
Human CSF-1 is required for the survival of human iPSC-derived Erythro-myeloid progenitors and microglia in the mouse brain
Hayk Davtyan (University of California, Irvine, USA)
Interactions between endothelial cells and cardiomyocytes regulate human cardiac organoid functionality
Holly Voges (University of Queensland)
Human intestinal organoids as a model for intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency
Jorik van Rijn (Utrecht University, The Netherlands)
Establishing novel enhanced differentiation protocols of human pluripotent stem cells into various cell lineages using the predictive computational framework, MOGRIFY
Joseph Chen (Monash University)
ASIC1a inhibition with novel spider venom peptide, Hi1a, for the treatment of cardiac ischemia-induced acidosis
Meredith Redd (University of Queensland)
Stem cell-derived human micro-lenses for lens toxicology and anti-cataract drug discovery
Michael O’Connor (Western Sydney University)
Bioengineered skeletal muscle for high-throughput functional screening
Richard Mills (University of Queensland)
Assessing the differentiation potential of human podocytes using NPHS2-GFP and NPHS1-GFP-iPSCs
Ricky Lau (Monash University)
6-8pm Networking event, food and refreshments
MONDAY June 18
9.00am Cardiac models
iPSCs for cardiac disease modeling & drug discovery
Joseph Wu (Stanford University, CA, USA)
9.30am
Human Engineered Cardiac Organoids for Screening Applications
James Hudson (University of Queensland, Australia)
10.00am Blood, Macrophages, microglial models
Computational platforms to define and predict cell behaviour
Christine Wells (University of Melbourne, Australia)
10.30am Morning refreshment break
11.00am
hPSC-derived microglia-like cells as a tool in understanding and treating Alzheimer’s disease
Matt Blurton-Jones (University of California, Irvine, CA, USA)
11.30am
Modelling leukaemia
Andrew Elefanty (Murdoch Children’s Research Institute)
12.00pm Neural models
Directing neural differentiation for disease modelling and cell therapy
Lorenz Studer (Memorial Sloan Kettering Cancer Center, New York, NY, USA)
12.30pm
Functional genomics approaches to human neurological diseases
Ernst Wolvetang (University of Queensland, Australia)
13.00pm Lunch
14.00pm
Using pluripotent stem cell models to study neuropsychiatric conditions
Carol Marchetto (Salk Institute, La Jolla, CA, USA)
14.30pm
Modelling retinal diseases with patient induced pluripotent stem cells
Alice Pebay (University of Melbourne, Australia)
15.00pm Models for drug discovery
A platform of hPSC-derived cell culture models: challenges and opportunities
Eugenia Jones (Cellular Dynamics International, Madison, WI, USA)
15.30pm
The Phenomics Discovery Initiative (PDi): bringing disease-relevant biology from academia into the industrial drug discovery pipeline
Paul Andrews (National Phenotypic Screening Centre, Dundee, UK)
16:00pm Afternoon refreshments
16.30pm Panel Discussion (Q&A)
How can the potential of human stem cell-derived models be harnessed for drug discovery?
Chair: Colin Pouton
Panel: Christine Mummery, Lorenz Studer, Paul Andrews, Ricardo Dolmetsch, Chris Langmead, Daniel Hoyer
18.00pm Close