A/Prof Tianhai Tian

Research Overview

Mathematical modelling of complex biological systems, including genetic regulatory networks, cell signalling transduction pathways, and cancer therapy. Inference of complex networks from big data.

Selected Publications

[1] Deng, Zhimin ; Zhang, Xinan ; Tian, Tianhai. "Inference of model parameters using particle filter algorithm and Copula distributions". In: IEEE/ACM transactions on computational biology and bioinformatics. 2020 ; Vol. 17. pp.1231-1240. https://doi.org/10.1109/TCBB.2018.2880974

[2] Wang, Junbai ; Wu, Qianqian ; Hu, Xiaohua Tony ; Tian, Tianhai. "An integrated approach to infer dynamic protein-gene interactions – a case study of the human P53 protein". In: Methods. 2016 ; Vol. 110. pp. 3-13. https://doi.org/10.1016/j.ymeth.2016.08.001

[3] Tian, Tianhai ; Harding, Angus ; Inder, Kerry ; Plowman, Sarah ; Parton, Robert G ; Hancock, John F. "Plasma membrane nanoswitches generate high-fidelity Ras signal transduction". In: Nature Cell Biology. 2007 ; Vol. 9, No. 8. pp. 905 - 914.

[4] Tian, Tianhai ; Xu, Songlin ; Gao, Junbin ; Burrage, Kevin. "Simulated maximum likelihood method for estimating kinetic rates in gene expression". In: Bioinformatics. 2007 ; Vol. 23, No. 1. pp. 84 - 91.

[5] Tian, Tianhai ; Burrage, Kevin. "Stochastic models for regulatory networks of the genetic toggle switch". In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 22. pp. 8372 - 8377.